Results 101 to 110 of about 6,101,774 (389)

CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells

Stem Cell Reports, 2015
To develop a culture system for large-scale production of mature hepatocytes, liver progenitor cells (LPCs) with a high proliferation potential would be advantageous.
Taketomo Kido, Yuta Koui, Kaori Suzuki, Ayaka Kobayashi, Yasushi Miura, Edward Y. Chern, Minoru Tanaka, Atsushi Miyajima   +7 more
doaj   +1 more source

Diversity, Stability, Recursivity, and Rule Generation in Biological System: Intra-inter Dynamics Approach

, 1998
Basic problems for the construction of a scenario for the Life are discussed. To study the problems in terms of dynamical systems theory, a scheme of intra-inter dynamics is presented.
Kaneko K., Kaneko K., Kaneko K., Kaneko K., Ko E., Kunihiko Kaneko, Turing A. M., Yamamoto T.   +7 more
core   +2 more sources

Differential evolution with generalized differentials

Journal of Computational and Applied Mathematics, 2011
AbstractIn this paper, we study the mutation operation of the differential evolution (DE) algorithm. In particular, we propose the differential of scaled vectors, called the ‘generalized differential’, as opposed to the existing scaled differential vector in the mutation of DE.
openaire   +2 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Automatic Differentiation Variational Inference

, 2016
Probabilistic modeling is iterative. A scientist posits a simple model, fits it to her data, refines it according to her analysis, and repeats. However, fitting complex models to large data is a bottleneck in this process.
Blei, David M., Gelman, Andrew, Kucukelbir, Alp, Ranganath, Rajesh, Tran, Dustin   +4 more
core  

Coherent differentiation

Mathematical Structures in Computer Science, 2023
AbstractThe categorical models of differential linear logic (LL) are additive categories and those of the differential lambda-calculus are left-additive categories because of the Leibniz rule which requires the summation of two expressions. This means that, as far as the differential lambda-calculus and differential LL are concerned, these models ...
openaire   +3 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

Xbra modulates the activity of linker region phosphorylated Smad1 during Xenopus development

Scientific Reports
The Bmp/Smad1 pathway plays a crucial role in developmental processes and tissue homeostasis. Mitogen-activated protein kinase (Mapk)/Erk mediated phosphorylation of Smad1 in the linker region leads to Smad1 degradation, cytoplasmic retention and ...
Santosh Kumar, Zobia Umair, Vijay Kumar, Ravi Shankar Goutam, Soochul Park, Unjoo Lee, Jaebong Kim   +6 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source