Results 151 to 160 of about 4,638,915 (335)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

iCAT as an open-source platform for axial rotation and high-resolution imaging of organoids and living organisms

Communications Biology
In dynamic light microscopy applications, imaging specimens from multiple angles while maintaining controlled temperature conditions is crucial for comprehensive and accurate analysis.
Ondřej Svoboda, Olga Machoňová, Petr Bartůněk   +2 more
doaj   +1 more source

Tissue-Specific Natural Synthesis of Galanthaminein Zephyranthes Species and Its Accumulation in Different In Vitro-Grown Organs Following Methyl Jasmonate Treatment

Plants
Galanthamine is an immensely valuable alkaloid exhibiting anti-cancer and antiviral activity. The cultivation of plant tissues in in vitro conditions is a good source for the synthesis and enrichment of secondary metabolites of commercial interest.
Rukaya Syeed, A. Mujib, Yashika Bansal, Mohammad Mohsin, Afeefa Nafees, Moien Qadir Malik, Jyoti Mamgain, Bushra Ejaz, Yaser Hassan Dewir, Katalin Magyar-Tábori   +9 more
doaj   +1 more source

Learning in Integer Latent Variable Models with Nested Automatic Differentiation [PDF]

, 2018
Daniel Sheldon, Kevin Winner, Debora Sujono   +2 more
openalex   +1 more source

Supplementary Figure 3 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network

, 2023
Marta Leytón Román, Inés López López, Elizabeth Guruceaga, Iosune Baraibar, Margarita Ecay, María Collantes, Ernest Nadal, Adrián Vallejo, Silvia Cadenas, Marta Echavarri-de Miguel, Jae Hwi Jang, Patxi San Martín‐Úriz, Laura Castro‐Labrador, Amaia Vilas‐Zornoza, David Lara‐Astiaso, Mariano Ponz‐Sarvisé, Christian Rolfo, Edgardo S. Santos, Luis E. Raez, Simona Taverna, Carmen Behrens, Walter Weder, Ignacio I. Wistuba, Silvestre Vicent, Ignacio Gil‐Bazo   +24 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The relationship between histological differentiation and disease recurrence of primary oral squamous cell carcinoma

, 2017
R Padma, A. Kalaivani, Sivapatham Sundaresan, Paulraj Sathish   +3 more
openalex   +1 more source

Supplementary Table 2 from Altered Expression of Neurotensin Receptors Is Associated with the Differentiation State of Prostate Cancer

, 2023
Stephanie L. Swift, Julie E. Burns, Norman J. Maitland   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

SAT0073 STAT3/STAT5 BALANCE AS A BIOMARKER IN RA: CTLA4-IG AND T CELL DIFFERENTIATION THROUGH STAT SIGNALING [PDF]

, 2019
Stefano Alivernini, Barbara Tolusso, Anna Laura Fedele, Clara Di Mario, Luca Petricca, Maria Rita Gigante, Gianfranco Ferraccioli, Elisa Gremese   +7 more
openalex   +1 more source