Results 181 to 190 of about 4,638,915 (335)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Glia Regulate the Timing of Photoreceptor Differentiation in the Drosophila Visual System. [PDF]
GliaRen Q, Chang WT, Rao Y.
europepmc +1 more source
Surgical Treatment of Differentiated Thyroid Cancer with Tracheal Invasion.
, 1998 M. Ebihara +7 more
openalex +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Automated characterization of the gray matter white matter distribution demonstrates age-related decline. [PDF]
Sci RepSong JY +7 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases. [PDF]
Cell DiscovZhu S, Yan MQ, Masson A, Chen W, Li YP.
europepmc +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Single-nucleus RNA sequencing identifies a novel tenogenic heterologous differentiation in endometrial carcinosarcomas: implications for diagnosis and tumor classification. [PDF]
J PatholGonzález-Martínez S +9 more
europepmc +1 more source