Results 211 to 220 of about 4,638,915 (335)

Calcium Oxalate Differentiates Human Monocytes Into Inflammatory M1 Macrophages [PDF]

, 2018
Paul R. Dominguez‐Gutierrez, Sergei Kusmartsev, Benjamin K. Canales, Saeed R. Khan   +3 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Wnt10a exhibit spatiotemporal singularity in the temporal changes of angiogenesis in regenerated pulp-like tissue. [PDF]

Inflamm Regen
Iida N, Hayashi Y, Futenma T, Sakatoku S, Sugita Y, Nakamura K, Nawa H.   +6 more
europepmc   +1 more source

Differential Games

, 1972
openaire   +2 more sources

Pyrometheus: Symbolic abstractions for XPU and automatically differentiated computation of combustion kinetics and thermodynamics [PDF]

Esteban Cisneros–Garibay, Henry Le Berre, D. Adam, Spencer H. Bryngelson, Jonathan B. Freund   +4 more
openalex   +1 more source

Dysregulated MicroRNA Involvement in Multiple Sclerosis by Induction of T Helper 17 Cell Differentiation [PDF]

, 2018
Chen Chen, Yifan Zhou, Jingqi Wang, Yaping Yan, Lisheng Peng, Wei Qiu   +5 more
openalex   +1 more source

Paraffin section observation of flower bud differentiation of Chimonanthus praecox in Kunming and comparison of the differentiation processes in different regions, China

, 2021
Sijin Li, Nan Yang, Long‐Qing Chen
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD. [PDF]

Int J Oral Sci
Feng H, Niu J, Chen Z, Yang G, Yuan G.
europepmc   +1 more source