T Cell-Specific Deficiency of Src Homology 2-Containing Protein Tyrosine Phosphatase 2 Ameliorates Psoriasis and Colitis by Promoting Treg Differentiation. [PDF]
Zhang S+7 more
europepmc +1 more source
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo+11 more
wiley +1 more source
APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells. [PDF]
Wang M+7 more
europepmc +1 more source
Nitric oxide‐forming nitrite reductases in the anaerobic ammonium oxidizer Kuenenia stuttgartiensis
Anammox bacteria remove fixed nitrogen from their environment via anaerobic ammonium oxidation (anammox) with nitrite as electron acceptor and dinitrogen gas as product. The first anammox step is the conversion of nitrite to nitric oxide by nitrite reductase.
Femke J. Vermeir+4 more
wiley +1 more source
The Effect of the Female Sex Hormone on Sexual Differentiation of the Gonads in Male Chick Embryos
Kiyoshi Masui, Kyôzi KONDÔ
openalex +2 more sources
Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno+12 more
wiley +1 more source
Enforced MYC expression directs a distinct transcriptional state during plasma cell differentiation. [PDF]
Vardaka P+11 more
europepmc +1 more source
ON THE OPERATIONAL CALCULUS WITH DIFFERENTIABLE FUNCTIONS
Léopoldo Nachbin
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In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li+5 more
wiley +1 more source
Metrnl/Meteorin-like/IL-41, a novel regulator of bone metabolism and disease activity in ankylosing spondylitis: based on multi-omics analysis. [PDF]
Li Z, Sun T, Zhao M, Xia L, Shen H.
europepmc +1 more source