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m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Adolescent sports participation and social-class health inequalities: evidence from CHNS. [PDF]

Front Public Health
Yu J, Lu Y, Zhao L.
europepmc   +1 more source

Clinical research in private hospitals: a perspective. [PDF]

J Transl Med
Rossier L, Snäkä T, Graciotti M, Hernandez M, Matzinger O, Bernier J, Kandalaft L.   +6 more
europepmc   +1 more source

Digital navigation as an access barrier: waiting times, equity, and universal health coverage in a digitalizing health system. [PDF]

Front Public Health
Memmel E, Kerschbaumer L.
europepmc   +1 more source

Policy frameworks for promoting public hospital development in major economies: implications for China. [PDF]

Front Public Health
Shu Y, Li Z, Xie R.
europepmc   +1 more source

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Differential response of neurotensin to methamphetamine self-administration.

Annals of the New York Academy of Sciences, 2008
Neurotensin (NT) is a tridecapeptide associated with extrapyramidal and limbic pathways and is thought to inhibit dopamine (DA) functions in nigrostriatal, mesocortical, and mesolimbic systems. Because of these effects, NT has been referred to as an endogenous neuroleptic.
Paul S, Frankel, Amanda J, Hoonakker, Glen R, Hanson   +2 more
openaire   +3 more sources