Results 221 to 230 of about 10,005 (276)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Advancing from Compliance to Innovation in Medical Education: a strategic roadmap for MEUs in colleges of Korean medicine based on FGI. [PDF]

J Pharmacopuncture
Lee MJ, Lee HY, Jin MH, Kim SK.
europepmc   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Digital navigation as an access barrier: waiting times, equity, and universal health coverage in a digitalizing health system. [PDF]

Front Public Health
Memmel E, Kerschbaumer L.
europepmc   +1 more source

Structural and role-based workplace mistreatment in clinical training: a cross-sectional study of intern and resident physicians. [PDF]

BMC Med Educ
Saka NE, Çeli̇k C, Koç GMK, Ata U.
europepmc   +1 more source

Victim-centered justice through profiling: clustering analysis of parent who suffered abuse. [PDF]

Front Psychol
Moret-Tatay C, Beneyto-Arrojo MJ, Iborra-Marmolejo I, Mosquera-Ordónez C, Jiménez-Ribera A, Sempere-Faus S.   +5 more
europepmc   +1 more source

Policy frameworks for promoting public hospital development in major economies: implications for China. [PDF]

Front Public Health
Shu Y, Li Z, Xie R.
europepmc   +1 more source

Financing Regimes and Case-Mix Complexity in Psychiatric Hospitals Beyond the Pandemic Shock-Insights from a Regional European Healthcare System. [PDF]

Healthcare (Basel)
Țîbîrnă A, Iliuta FP, Manea MC, Manea M.   +3 more
europepmc   +1 more source