Results 71 to 80 of about 196,920 (284)
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Deployment and Impact of Support Staff in Schools : The Impact of Support Staff in Schools (Results from Strand 2, Wave 2) [PDF]
, 2009 This study was designed to obtain up to date and reliable data on the deployment and characteristics of support staff and the impact of support staff on pupil outcomes and teacher workloads. The study covered schools in England and Wales.
Bassett, Paul +7 more
core +1 more source
Enhancing Brand Equity Through Sustainability: Waste Recycling [PDF]
, 2015 Unlike many existing research studies that explain reverse marketing from a purchasing perspective, this study recognizes it as an honest effort made by managers aiming to promote sustainability by purposefully managing waste and discusses the spillover ...
Gupta, Suraksha
core +1 more source
BMC Public HealthBACKGROUND: The Palestinian National Referral System for Abused Women, issued in 2022, was created to assist individuals affected by family-based violence by providing them with protection and offering standardized procedures for addressing the needs of women and children affected by violence and abuse.
Salameh, Naeem +2 more
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source
A Happiness Approach to Cost-Benefit Analysis [PDF]
, 2013 Subjective well-being (SWB) surveys ask respondents to quantify their overall or momentary happiness or life-satisfaction, or pose similar questions about other aspects of respondents\u27 mental states.
Foglia, Andrew T., Jennings, Andrew K.
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source
Immunology, 1999 We have previously demonstrated that intranasal (i.n.) administration of the major encephalitogenic peptide, Ac1–9 of myelin basic protein (MBP), inhibited T‐cell responsiveness in vitro and induced tolerance in the H‐2u mouse model of experimental autoimmune encephalomyelitis (EAE). The peptide analogue Ac1–9[4Y] with high‐affinity binding to the I‐Au
B, Metzler, D C, Wraith
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Changing patterns in the steering of the University in Italy: funding rules and doctoral programmes [PDF]
The paper aim is to highlight the transformation of the state-university relationships in Italy, because of the introduction of the autonomy-accountability principles for the university government.
Bianca Poti', Emanuela Reale
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