Results 91 to 100 of about 58,590 (281)

Association Between Serum Electrolyte Disturbances and Glasgow Coma Scale Score in Patients With Diffuse Axonal Injury [PDF]

, 2022
Hamid Behzadnia, Mesbah Dibavand, Mohammadreza Emamhadi, Sasan Andalib, Mahsa Pakseresht Mogharab, Naghmeh Khoshsima, Zoheir Reihanian   +6 more
openalex   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

The Clinical Journey and Challenges of Diffuse Axonal Injury (DAI) in a Severe Traumatic Brain Injury – A Case Report

Galicia Clínica
Diffuse axonal injury (DAI) arises as a severe consequence of traumatic brain injury (TBI), characterized by axonal misalignment, stretching, or shearing.
Bárbara Paracana, Ana Oliveira, Eduardo Ribeiro, Mariana Sousa   +3 more
doaj   +1 more source

Progress of Research on Diffuse Axonal Injury after Traumatic Brain Injury

Neural Plasticity, 2016
The current work reviews the concept, pathological mechanism, and process of diagnosing of DAI. The pathological mechanism underlying DAI is complicated, including axonal breakage caused by axonal retraction balls, discontinued protein transport along ...
Junwei Ma, Kai Zhang, Zhimin Wang, Gang Chen   +3 more
doaj   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Altered Intracortical Inhibition in Chronic Traumatic Diffuse Axonal Injury

Frontiers in Neurology, 2018
BackgroundOveractivation of NMDA-mediated excitatory processes and excess of GABA-mediated inhibition are attributed to the acute and subacute phases, respectively, after a traumatic brain injury (TBI).
Cintya Yukie Hayashi, Iuri Santana Neville, Priscila Aparecida Rodrigues, Ricardo Galhardoni, Ricardo Galhardoni, André Russowsky Brunoni, Ana Luiza Zaninotto, Ana Luiza Zaninotto, Vinicius Monteiro de Paula Guirado, Ana Sofia Cueva, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva   +12 more
doaj   +1 more source

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source

Diffuse Axonal Injury: Epidemiology, Outcome and Associated Risk Factors

Frontiers in Neurology, 2016
Diffuse axonal injury (DAI), a type of traumatic injury, is known for its severe consequences. However, there are few studies describing the outcomes of DAI and the risk factors associated with it.
Rita de Cassia Almeida Vieira, Wellingson Silva Paiva, Daniel Vieira de Oliveira, Manoel Jacobsen Teixeira, Almir Ferreira de Andrade, Regina Marcia Cardoso de Sousa   +5 more
doaj   +1 more source

Traumatic midline subarachnoid hemorrhage on initial computed tomography as a marker of severe diffuse axonal injury.

Journal of Neurosurgery, 2018
OBJECTIVEThe objective of this study was to test the hypothesis that midline (interhemispheric or perimesencephalic) traumatic subarachnoid hemorrhage (tSAH) on initial CT may implicate the same shearing mechanism that underlies severe diffuse axonal ...
Daddy Mata-Mbemba, S. Mugikura, A. Nakagawa, T. Murata, K. Ishii, S. Kushimoto, T. Tominaga, Shoki Takahashi, K. Takase   +8 more
semanticscholar   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source