Results 241 to 250 of about 58,590 (281)
ABSTRACT A 14‐year‐old female with juvenile systemic lupus erythematosus (jSLE) presented with a life‐threatening and previously unreported triad: the simultaneous onset of acute pancreatitis, severe axonal polyneuropathy, and autoimmune Type 1 Diabetes (T1D).
Laiba Hashmi +11 more
wiley +1 more source
RVLM C1 Neurons Innervate Sacral as well as Thoracolumbar Autonomic Preganglionic Neurons in the Rat
Axons expressing the adrenaline‐synthesizing enzyme, phenylethanolamine N‐methyltransferase (PNMT), project widely throughout the spinal cord. Many of these axons are from C1 neurons of the rostral ventrolateral medulla. We confirm that dense arrays of PNMT‐expressing, C1‐derived axons surround thoracolumbar sympathetic preganglionic neurons, many of ...
I. J. Llewellyn‐Smith +5 more
wiley +1 more source
Glucagon‐Like Peptide‐1 Targets in the Human Nodose Ganglion
Our findings demonstrate that the human nodose ganglion expresses Glp1r mRNA and reveal species similarities and differences in Glp1r expression between humans and mice. ABSTRACT Given the rapidly expanding clinical use of glucagon‐like peptide‐1 receptor (GLP1R) agonists—well‐known for their antidiabetic and antiobesity effects—it is increasingly ...
Warda Merchant +3 more
wiley +1 more source
The Role of MRI in Debunking the Fallacy of “Mild” Traumatic Brain Injury
ABSTRACT Mild traumatic brain injury (mTBI) is a prevalent yet often overlooked public health concern due to the absence of detectable abnormalities on CT or conventional MRI scans. Approximately 18.3%–31.3% of mTBI patients experience persistent symptoms 3–6 months post‐injury, despite normal imaging results, making diagnosis and treatment challenging.
Xingye Chen +3 more
wiley +1 more source
ABSTRACT Background Traumatic Brain Injury (TBI) is a global health concern, with mild TBI (mTBI) being the most common form. Despite its prevalence, accurately diagnosing mTBI remains a significant challenge. While advanced neuroimaging techniques like diffusion tensor imaging (DTI) offer promise for more robust diagnosis, their clinical application ...
Christian John A. Saludar +8 more
wiley +1 more source
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu +6 more
wiley +1 more source
ABSTRACT Introduction/Aims Nerve regeneration after injury must occur in a timely fashion to restore function. Current methods of assessment provide limited information following trauma, resulting in delayed management and suboptimal outcomes. In this study, we evaluated the ability of diffusion magnetic resonance imaging (MRI) and a mathematical model
Isaac Manzanera Esteve +16 more
wiley +1 more source
Frequency‐dependent multidimensional (ωMD) diffusion‐relaxation MRI captures microstructural information beyond conventional voxel‐averaged metrics. Here, we evaluate ωMD‐MRI reproducibility in ex vivo mouse brains using a high‐performance micro‐imaging system.
Pak Shing Kenneth Or +7 more
wiley +1 more source
Reflections on Consciousness in Intensive Care
ABSTRACT Evaluating consciousness in intensive care is pivotal to relieving suffering with analgesic or sedative drugs and in prognosis and diagnoses. The usual clinical perspective is to equate consciousness with responsiveness, assuming functional motor responses and sympathetic activity of the patient. Clinical diagnoses of coma may be wrong in more
Michael Broomé, Tiit Mathiesen
wiley +1 more source

