Results 51 to 60 of about 75,613 (232)

Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation through a Toll-like Receptor-Related Pathway after Diffuse Axonal Injury in Rats

BioMed Research International, 2020
Objective We have previously demonstrated that inflammation induced by toll-like receptors (TLRs) 2/4 exert cerebral deleterious effects after diffuse axonal injury (DAI); however, the underlying mechanisms are not fully understood.
Yonglin Zhao, Xinglin Wei, Weimiao Li, Changyou Shan, Jinning Song, Ming Zhang   +5 more
semanticscholar   +1 more source

Influence of liposome-mediated APOE3 gene transfection of brain tissue on diffuse axonal injury, caused by traumatic brain injury, in experiment

Ukrainian Neurosurgical Journal, 2011
The goal of study was to estimate the structural damage of axons in rats with severe traumatic brain injury (TBI), and the possibilities of such disorders correction by means of gene therapy that launches the synthesis of e3 isoform of ...
Vadym Biloshytsky, Sergey Mikhalsky, Tatyana Kvitnitskaya-Ryzhova   +2 more
doaj   +1 more source

Immediate induction of varicosities by transverse compression but not uniaxial stretch in axon mechanosensation

Acta Neuropathologica Communications, 2022
Uniaxial stretch is believed to drive diffuse axonal injury (DAI) in mild traumatic brain injury (mTBI). Axonal varicosities are enlarged structures along axonal shafts and represent a hallmark feature of DAI.
Chao Sun, Lin Qi, Yang Cheng, Yi Zhao, Chen Gu   +4 more
doaj   +1 more source

SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury [PDF]

, 2015
Diffuse axonal injury (DAI) is a common feature of severe traumatic brain injury (TBI) and may also be a predominant pathology in mild TBI or “concussion”.
Cullen, D. Kacy, Johnson, Victoria E., Siman, Robert, Smith, Douglas H., Stewart, William, Weber, Maura T.   +5 more
core   +1 more source

Diffuse axonal injury in head trauma. [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1989
Diffuse axonal injury (DAI) as defined by detailed microscopic examination was found in 34 of 80 consecutive cases of head trauma surviving for a sufficient length of time to be clinically assessed by the Royal Adelaide Hospital Neurosurgery Unit.
Blumbergs, P., Jones, N., North, J.
openaire   +4 more sources

Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities [PDF]

, 2011
Alzheimer\u27s disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins.
Brody, David L, Holtzman, David M, LaFerla, Frank M, Tran, Hien T   +3 more
core   +2 more sources

Current Opportunities for Clinical Monitoring of Axonal Pathology in Traumatic Brain Injury

Frontiers in Neurology, 2017
Traumatic brain injury (TBI) is a multidimensional and highly complex disease commonly resulting in widespread injury to axons, due to rapid inertial acceleration/deceleration forces transmitted to the brain during impact.
Parmenion P. Tsitsopoulos, Parmenion P. Tsitsopoulos, Sami Abu Hamdeh, Niklas Marklund, Niklas Marklund   +4 more
doaj   +1 more source

Traumatic axonal injury in the spinal cord evoked by traumatic brain injury [PDF]

, 2008
Although it is well known that traumatic brain injury (TBI) evokes traumatic axonal injury (TAI) within the brain, TBI-induced axonal damage in the spinal cord (SC) has been less extensively investigated.
Bukovics, Péter, Büki, András, Czeiter, Endre, Dóczi, Tamás, Kövesdi, Erzsébet, Lückl, János, Pál, József   +6 more
core   +1 more source

Clinical-pathological study on β-APP, IL-1β, GFAP, NFL, Spectrin II, 8OHdG, TUNEL, miR-21, miR-16, miR-92 expressions to verify DAI-diagnosis, grade and prognosis [PDF]

, 2018
Traumatic brain injury (TBI) is one of the most important death and disability cause, involving substantial costs, also in economic terms, when considering the young age of the involved subject. Aim of this paper is to report a series of patients treated
A Frati, AA Hyder, AM Palmer, AW Selassie, B Buller, B Roozenbeek, CJ Murray, D Thurman, DH Smith, DK Menon, DM Stein, DR Li, EM Graham, F Masson, F Tagliaferri, FE Sherriff, FM Barabas, FM Shahim, G Illerhaus, H Bayir, HA Kontos, I Humphreys, JB Redell, JB Redell, JB Redell, JF Geddes, JH Adams, JT Povlishock, JT Povlishock, K Blennow, K Dams-O’Connor, K Fukuda, K Sakai, KM O’Connell, L Tao, M Oehmichen, M Oehmichen, M Ogata, M Valiyaveettil, M Ziu, MA Ansari, MB Grosjean, N Stoicea, OG Bhalala, PR Turner, R Sandhir, RM Chesnut, S Griffiths-Jones, S Griffiths-Jones, S Schiavone, S Thornhill, S Yokobori, SK Kwon, T Frugier, T Strickland, TY Sun, V Pietro Di, VA Tyurin, W Peeters, WL Maxwell, WX Wang, X Ge, X Ge, Y Li, Y Zhang, Z Hu   +65 more
core   +2 more sources

Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury

Journal of Neuroinflammation, 2010
Background Diffuse axonal injury in patients with traumatic brain injury (TBI) can be associated with morbidity ranging from cognitive difficulties to coma.
Chrzaszcz MaryAnn, Venkatesan Charu, Choi Nicole, Wainwright Mark S   +3 more
doaj   +1 more source