Results 61 to 70 of about 22,064 (234)

Regional Differences in Susceptibility to Hypoxic-Ischemic Injury in the Preterm Brain: Exploring the Spectrum from White Matter Loss to Selective Grey Matter Injury in a Rat Model

Neurology Research International, 2012
Models of premature brain injury have largely focused on the white matter injury thought to underlie periventricular leukomalacia (PVL). However, with increased survival of very low birth weight infants, injury patterns involving grey matter are now ...
D. B. Selip, L. L. Jantzie, M. Chang, M. C. Jackson, E. C. Fitzgerald, G. Boll, A. Murphy, F. E. Jensen   +7 more
doaj   +1 more source

Magnetic resonance susceptibility weighted in evaluation of cerebrovascular diseases

The Egyptian Journal of Radiology and Nuclear Medicine, 2020
Background Cerebrovascular diseases are considered a very hard burden as they may lead to poor outcome, and they are considered the second most common cause of morbidity and mortality after coronary artery disease.
Amr Yehia Abd Elmotelb Sultan, Khalid Ismael ElShafey, Omar Ahmed Hassanien, Rasha Mahmoud Dawoud   +3 more
doaj   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

The Clinical Journey and Challenges of Diffuse Axonal Injury (DAI) in a Severe Traumatic Brain Injury – A Case Report

Galicia Clínica
Diffuse axonal injury (DAI) arises as a severe consequence of traumatic brain injury (TBI), characterized by axonal misalignment, stretching, or shearing.
Bárbara Paracana, Ana Oliveira, Eduardo Ribeiro, Mariana Sousa   +3 more
doaj   +1 more source

Progress of Research on Diffuse Axonal Injury after Traumatic Brain Injury

Neural Plasticity, 2016
The current work reviews the concept, pathological mechanism, and process of diagnosing of DAI. The pathological mechanism underlying DAI is complicated, including axonal breakage caused by axonal retraction balls, discontinued protein transport along ...
Junwei Ma, Kai Zhang, Zhimin Wang, Gang Chen   +3 more
doaj   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Altered Intracortical Inhibition in Chronic Traumatic Diffuse Axonal Injury

Frontiers in Neurology, 2018
BackgroundOveractivation of NMDA-mediated excitatory processes and excess of GABA-mediated inhibition are attributed to the acute and subacute phases, respectively, after a traumatic brain injury (TBI).
Cintya Yukie Hayashi, Iuri Santana Neville, Priscila Aparecida Rodrigues, Ricardo Galhardoni, Ricardo Galhardoni, André Russowsky Brunoni, Ana Luiza Zaninotto, Ana Luiza Zaninotto, Vinicius Monteiro de Paula Guirado, Ana Sofia Cueva, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva   +12 more
doaj   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Diffuse Axonal Injury: Epidemiology, Outcome and Associated Risk Factors

Frontiers in Neurology, 2016
Diffuse axonal injury (DAI), a type of traumatic injury, is known for its severe consequences. However, there are few studies describing the outcomes of DAI and the risk factors associated with it.
Rita de Cassia Almeida Vieira, Wellingson Silva Paiva, Daniel Vieira de Oliveira, Manoel Jacobsen Teixeira, Almir Ferreira de Andrade, Regina Marcia Cardoso de Sousa   +5 more
doaj   +1 more source

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source