Results 1 to 10 of about 375 (118)

Diffuse Cerebral Sclerosis of Schilder [PDF]

open access: hybridDefinitions, 2020
A rare congenital demyelinating disorder affecting the central nervous system. It is characterized by a demyelinating destructive lesion affecting an entire brain lobe or hemisphere.
semanticscholar   +3 more sources

Defining the natural history of tumefactive demyelination: A retrospective cohort of 257 patients

open access: yesAnnals of Clinical and Translational Neurology, Volume 10, Issue 9, Page 1544-1555, September 2023., 2023
Abstract Objective To describe demographic, clinical, and radiographic features of tumefactive demyelination (TD) and identify factors associated with severe attacks and poor outcomes. Methods Retrospective review of TD cases seen at Mayo Clinic, 1990–2021.
Mahboubeh Fereidan‐Esfahani   +8 more
wiley   +1 more source

MS Variants (ORP-38) [PDF]

open access: yesNeurology Letters, 2023
In this lecture, multiple sclerosis variants will be discussed, which include Solitary Sclerosis, Schilder's disease, Baló's concentric sclerosis, Marburg variant of multiple sclerosis.
Ebrahim Kouchaki
doaj  

Silent Tumefactive Demyelinating Lesions and Radiologically Isolated Syndrome

open access: yesCase Reports in Neurological Medicine, Volume 2018, Issue 1, 2018., 2018
Demyelinating lesions larger than 2 cm in diameter, with or without edema, are known as tumefactive demyelinating lesions (TDLs). They constitute a rare inflammatory demyelinating disorder of the central nervous system. TDLs are typically characterized by headaches, cortical symptoms such as aphasia, hemiparesis, hemisensory deficits, seizures, and ...
Ozgul Ekmekci   +2 more
wiley   +1 more source

A Case of Acute Disseminated Encephalomyelitis in a Middle‐Aged Adult

open access: yesCase Reports in Neurological Medicine, Volume 2015, Issue 1, 2015., 2015
Objectives. Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disorder that is often preceded by infection or recent vaccination. Encephalopathy and focal neurological deficits are usually manifest several weeks after a prodromal illness with rapidly progressive neurologic decline.
Nicole Mahdi   +4 more
wiley   +1 more source

Heterogeneity in Multiple Sclerosis: Scratching the Surface of a Complex Disease

open access: yesAutoimmune Diseases, Volume 2011, Issue 1, 2011., 2011
Multiple Sclerosis (MS) is the most common demyelinating disease of the central nervous system. Although the etiology and the pathogenesis of MS has been extensively investigated, no single pathway, reliable biomarker, diagnostic test, or specific treatment have yet been identified for all MS patients.
Giulio Disanto   +9 more
wiley   +1 more source

Obsessive–Compulsive Symptoms in Neurologic Disease: A Review

open access: yesBehavioural Neurology, Volume 5, Issue 1, Page 3-10, 1992., 1992
Obsessive–compulsive disorder (OCD) is an increasingly recognized disorder with a prevalence of 2–3% (Robins et al., 1984). Once thought to be psychodynamic in origin, OCD is now generally recognized as having a neurobiological cause. Although the exact pathophysiology of OCD in its pure form remains unknown, there are numerous reports of obsessive ...
M. S. George   +2 more
wiley   +1 more source

Long-term Outcome of Schilder Disease Treated With Interferon-β

open access: yesPediatrics, 2019
In this case study, we implicate the disease-modifying potential of interferon-β for relapsing Schilder disease. Schilder disease, also termed diffuse myelinoclastic sclerosis, is characterized by a large demyelinating lesion involving 1 or both sides of
Wei-Sheng Lin, M. Kuo, S. Peng, P. Fan
semanticscholar   +1 more source

A COMPARATIVE STUDY OF 16 CASES OF DIFFUSE SCLEROSIS WITH SPECIAL REFERENCE TO THE HISTOPATHOLOGICAL FINDINGS

open access: yesActa Neurologica Scandinavica, 1961
The general denomination of “diffuse sclerosis” or Schilder’s disease includes many morbid manifestations which, in spite of remarkable clinical and pathological differences, are fundamentally characterised by an extensive destruction of the myelin ...
E. Christensen, J. Melchior, S. Negri
semanticscholar   +1 more source

HEREDITARY PROGRESSIVE CEREBRAL LEUCODYSTROPHY

open access: yesActa Neurologica Scandinavica, 1961
Hereditary progressive cerebral leucodystrophy is the designation introduced by Bielschowsky & Henneberg (1928) for those disease groups which may be regarded as hereditary abiotrophies, the terminal stage of which is widespread and elective destruction ...
E. Hansen, S. Olsen, C. Plum
semanticscholar   +1 more source

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