Results 1 to 10 of about 375 (118)
Diffuse Cerebral Sclerosis of Schilder [PDF]
A rare congenital demyelinating disorder affecting the central nervous system. It is characterized by a demyelinating destructive lesion affecting an entire brain lobe or hemisphere.
semanticscholar +3 more sources
Defining the natural history of tumefactive demyelination: A retrospective cohort of 257 patients
Abstract Objective To describe demographic, clinical, and radiographic features of tumefactive demyelination (TD) and identify factors associated with severe attacks and poor outcomes. Methods Retrospective review of TD cases seen at Mayo Clinic, 1990–2021.
Mahboubeh Fereidan‐Esfahani+8 more
wiley +1 more source
In this lecture, multiple sclerosis variants will be discussed, which include Solitary Sclerosis, Schilder's disease, Baló's concentric sclerosis, Marburg variant of multiple sclerosis.
Ebrahim Kouchaki
doaj
Silent Tumefactive Demyelinating Lesions and Radiologically Isolated Syndrome
Demyelinating lesions larger than 2 cm in diameter, with or without edema, are known as tumefactive demyelinating lesions (TDLs). They constitute a rare inflammatory demyelinating disorder of the central nervous system. TDLs are typically characterized by headaches, cortical symptoms such as aphasia, hemiparesis, hemisensory deficits, seizures, and ...
Ozgul Ekmekci+2 more
wiley +1 more source
A Case of Acute Disseminated Encephalomyelitis in a Middle‐Aged Adult
Objectives. Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disorder that is often preceded by infection or recent vaccination. Encephalopathy and focal neurological deficits are usually manifest several weeks after a prodromal illness with rapidly progressive neurologic decline.
Nicole Mahdi+4 more
wiley +1 more source
Heterogeneity in Multiple Sclerosis: Scratching the Surface of a Complex Disease
Multiple Sclerosis (MS) is the most common demyelinating disease of the central nervous system. Although the etiology and the pathogenesis of MS has been extensively investigated, no single pathway, reliable biomarker, diagnostic test, or specific treatment have yet been identified for all MS patients.
Giulio Disanto+9 more
wiley +1 more source
Obsessive–Compulsive Symptoms in Neurologic Disease: A Review
Obsessive–compulsive disorder (OCD) is an increasingly recognized disorder with a prevalence of 2–3% (Robins et al., 1984). Once thought to be psychodynamic in origin, OCD is now generally recognized as having a neurobiological cause. Although the exact pathophysiology of OCD in its pure form remains unknown, there are numerous reports of obsessive ...
M. S. George+2 more
wiley +1 more source
Long-term Outcome of Schilder Disease Treated With Interferon-β
In this case study, we implicate the disease-modifying potential of interferon-β for relapsing Schilder disease. Schilder disease, also termed diffuse myelinoclastic sclerosis, is characterized by a large demyelinating lesion involving 1 or both sides of
Wei-Sheng Lin, M. Kuo, S. Peng, P. Fan
semanticscholar +1 more source
The general denomination of “diffuse sclerosis” or Schilder’s disease includes many morbid manifestations which, in spite of remarkable clinical and pathological differences, are fundamentally characterised by an extensive destruction of the myelin ...
E. Christensen, J. Melchior, S. Negri
semanticscholar +1 more source
HEREDITARY PROGRESSIVE CEREBRAL LEUCODYSTROPHY
Hereditary progressive cerebral leucodystrophy is the designation introduced by Bielschowsky & Henneberg (1928) for those disease groups which may be regarded as hereditary abiotrophies, the terminal stage of which is widespread and elective destruction ...
E. Hansen, S. Olsen, C. Plum
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