Results 91 to 100 of about 25,184 (248)

Precision Oncology for Pediatric Solid Tumors Using In‐Hospital Pediatric/AYA Malignancy‐Specific Panel Sequencing

Cancer Science, EarlyView.
Our findings indicate that a pediatric/AYA‐specific targeted panel deployed in a hospital can deliver rapid, clinically actionable molecular insights with high diagnostic and prognostic yield. This complements larger sequencing platforms by offering speed, focused content, and easier interpretation.
Masato Kojima, Sho Kurihara, Isamu Saeki, Ryo Touge, Keigo Nakashima, Shuhei Karakawa, Fumiyuki Yamasaki, Satoshi Okada, Eiso Hiyama   +8 more
wiley   +1 more source

Diffuse midline glioma of the brainstem: genetic features, complications and treatment prospects

Опухоли головы и шеи
Diffuse midline glioma of the brain is a rare but very aggressive and resistant glial tumor. This pathology is characterized by impossibility of radical surgical treatment, radioresistance, resistance to drug treatment, high morbidity in children, low ...
A. M. Kryanev, I. D. Rozanov, S. S. Lebedev, D. N. Grekov, K. S. Titov, T. A. Yakusheva, M. Kh. Salpagarov   +6 more
doaj   +1 more source

Prospective inter‐individual analysis of quality‐adjusted life years (QALYs) in brain tumor patients: A comprehensive assessment of health preferences

International Journal of Cancer, Volume 158, Issue 5, Page 1250-1261, 1 March 2026.
What's New? Eloquent intracranial tumors present unique challenges in neurosurgical treatment due to their proximity to critical functional areas of the brain. This prospective, single‐center cohort study quantified real‐time changes in patients' subjective burden of health impairments using the Time Trade‐Off and Standard Gamble methods, providing ...
Lisa S. Hönikl, Anna Kelm, Sandro M. Krieg, Bernhard Meyer, Vicki M. Butenschoen   +4 more
wiley   +1 more source

Diffuse midline glioma, H3-K27M mutant: Awareness leads to identification

Glioma, 2019
Midline astrocytic neoplasms have distinct molecular characteristics, quite different from astrocytic neoplasms with similar morphology but not located in the midline.
Sadhana Tiwari, Ishita Pant, Sujata Chaturvedi, Gurbachan Singh   +3 more
doaj   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

MRI comparative study of diffuse midline glioma, H3 K27-altered and glioma in the midline without H3 K27-altered

BMC Neurology, 2022
Purpose The MRI features of Diffuse midline glioma, H3 K27-altered and glioma in the midline without H3 K27-altered were compared and analyzed, and the changes in the apparent diffusion coefficient (ADC) of the two groups were quantitatively analyzed ...
Ji-ping Zhao, Xue-jun Liu, Hao-zhi Lin, Chun-xiao Cui, Ying-jie Yue, Song Gao, Hong-zhang Xu   +6 more
doaj   +1 more source

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for WHO CNS5 adult‐type diffuse gliomas

Brain Pathology, Volume 36, Issue 2, March 2026.
ADAPTR recommendations for Adult‐type Diffuse Gliomas in Resource‐restrained settings. Abstract The fifth edition of the WHO classification of CNS Tumors (WHO CNS5) has revised the diagnostic and grading criteria for Adult‐type Diffuse Gliomas (ADGs) by integrating molecular parameters with histologic features.
Vani Santosh, Chitra Sarkar, Shilpa Rao, Ho‐Keung Ng, Junji Shibahara, Maysa Al‐Hussaini, Michael E. Buckland, Sung‐Hye Park, Tarik Tihan, Pieter Wesseling, David N. Louis, Takashi Komori   +11 more
wiley   +1 more source

The 2016 World Health Organization Classification of tumours of the Central Nervous System: what the paediatric neuroradiologist needs to know [PDF]

, 2016
The recently published 2016 World Health Organization (WHO) classification of tumours of the Central Nervous System (CNS) introduces a number of significant changes from the previous edition.
Carney, O, Chhabda, S, D'Arco, F, Jacques, TS, Mankad, K   +4 more
core   +1 more source

Combined Delivery of CuO Nanoparticles and HIF‐1α Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
Encapsulated acriflavine (ACF) and copper oxide nanoparticles (CuO NPs) are coreleased from coaxial nanofibers, producing synergistic antiglioblastoma multiforme effects. ACF suppresses the hypoxia‐inducible factor 1α pathway related to many downstream factors for tumor growth, while CuO NPs generate reactive oxygen species that assist cuproptosis ...
Daewoo Han, Iris S. Weitz, Hasan Slika, Betty Tyler, Andrew J. Steckl   +4 more
wiley   +1 more source

GABAergic neuron-to-glioma synapses in diffuse midline gliomas

Nature
Abstract High-grade gliomas (HGGs) are the leading cause of brain cancer-related death. HGGs include clinically, anatomically and molecularly distinct subtypes that stratify into diffuse midline gliomas (DMGs), such as H3K27M -altered diffuse intrinsic pontine glioma, and ...
Tara Barron, Belgin Yalçın, Minhui Su, Youkyeong Gloria Byun, Avishai Gavish, Kiarash Shamardani, Haojun Xu, Lijun Ni, Neeraj Soni, Vilina Mehta, Samin Maleki Jahan, Yoon Seok Kim, Kathryn R. Taylor, Michael B. Keough, Michael A. Quezada, Anna C. Geraghty, Rebecca Mancusi, Linh Thuy Vo, Enrique Herrera Castañeda, Pamelyn J. Woo, Claudia K. Petritsch, Hannes Vogel, Kai Kaila, Michelle Monje   +23 more
openaire   +3 more sources