Results 111 to 120 of about 25,184 (248)

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas [PDF]

, 2014
Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous p.Lys27Met (K27M) mutations in
Albrecht, Steffen, Bechet, Denise, Benlimane, Naciba, David Allis, C., Ellezam, Benjamin, Faury, Damien, Fiset, Pierre-Olivier, Gielen, Gerrit G. H., Jabado, Nada, Kieran, Mark W., Korshunov, Andrey, Lewis, Peter W., Ligon, Keith L., Lu, Chao, Pfister, Stefan M., Pietsch, Torsten, Rousso, Caterina   +16 more
core   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, Volume 13, Issue 5, 27 January 2026.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy. [PDF]

, 2018
Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo- and radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T-cells, such as chimeric antigen receptor (CAR) T-cells, may represent a ...
Almeida, Neil D, Chuntova, Pavlina, Downey, Kira M, Hegde, Bindu, Okada, Hideho   +4 more
core  

ONC201 (Dordaviprone) in Recurrent H3 K27M–Mutant Diffuse Midline Glioma

Journal of Clinical Oncology
PURPOSE Histone 3 (H3) K27M–mutant diffuse midline glioma (DMG) has a dismal prognosis with no established effective therapy beyond radiation. This integrated analysis evaluated single-agent ONC201 (dordaviprone), a first-in-class imipridone, in ...
I. Arrillaga-Romany, Sharon L Gardner, Y. Odia, D. Aguilera, J. Allen, Tracy T Batchelor, N. Butowski, Clark C. Chen, T. Cloughesy, Andrew Cluster, J. D. de Groot, Karan S. Dixit, Jerome J Graber, A. Haggiagi, Rebecca A. Harrison, Albert Kheradpour, L. Kilburn, Sylvia C. Kurz, Guangrong Lu, T. MacDonald, M. Mehta, A. Melemed, P. Nghiemphu, S. Ramage, N. Shonka, Ashley Sumrall, R. Tarapore, Lynne P. Taylor, Y. Umemura, P. Wen   +29 more
semanticscholar   +1 more source

Cerebral Abscess Masquerading as Tuberculoma in a Post‐Renal Transplant Chronic Kidney Disease Patient: A Diagnostic and Therapeutic Challenge

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Solid organ transplant recipients are at increased risk of acquiring serious infections. We present a case of a 48‐year‐old male with a history of renal transplantation in 2012, chronic kidney disease (CKD) Stage 4, hypertension, uncontrolled diabetes mellitus, and prior tuberculous pleural effusion.
Sakib Abrar, Ibrahim Khalil, Md. Imran Hossain, Sunjida Amin Promi   +3 more
wiley   +1 more source

Anatomo‐Electro‐Clinical Features of Parietal Lobe Epilepsy: Insights From Scalp Video‐Electroencephalography

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Interictal and ictal discharges in lateral superior parietal lobule epilepsy are predominantly recorded in centroparietal region electrodes. The initial ictal semiology of different parietal lobe epilepsy subregions is distinct and specific, with minimal overlap, reflecting early propagation networks.
Huijuan Wan, Xuemin Zhao, Wenhan Hu, Chao Zhang, Xiu Wang, Zhong Zheng, Shengsong Wang, Dandan Liu, Lin Sang, Xianghong Meng, Kai Zhang, Xiaoqiu Shao   +11 more
wiley   +1 more source

Optical biopsy identification and grading of gliomas using label-free visible resonance Raman spectroscopy. [PDF]

, 2019
Glioma is one of the most refractory types of brain tumor. Accurate tumor boundary identification and complete resection of the tumor are essential for glioma removal during brain surgery.
Alfano, Robert R, Cheng, Gangge, Liu, Cheng-Hui, Shi, Lingyan, Wang, Kai, Wu, Binlin, Yu, Xinguang, Zhang, Chunyuan, Zhang, Lin, Zhao, Mingyue, Zhou, Yan, Zhu, Ke, Zong, Rui   +12 more
core   +1 more source

Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models [PDF]

, 2017
Purpose: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a ...
Colapietro, Alessandro, Di Cesare, Ernesto, Festuccia, Claudio, Fox, Judith A., Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Mattei, Claudia, Rossi, Giulia, Ventura, Luca, Vetuschi, Antonella, Vitale, Flora   +11 more
core   +1 more source

The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo [PDF]

, 2012
Background: Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior
Ding, Jianbo, Guo, Lin, Liu, Yingchao, Lu, Renquan, Mo, Wei, Wang, Huijie, Wong, Eric T., Wu, Chengsheng, Yu, Min   +8 more
core   +1 more source

RARE-30. PEDIATRIC GLIOBLASTOMA IN THE POST-TEMOZOLOMIDE ERA: OUTCOMES AND CHARACTERISTICS [PDF]

, 2019
INTRODUCTION Glioblastoma (GBM) is the most common brain tumor, however, is a rare occurrence in children and is poorly characterized. We evaluated the characteristics and outcomes of pediatric GBM (pGBM).
Aghi, Manish, Berger, Mitchel, Chandra, Ankush, Gupta, Nalin, McDermott, Mike, Oh, Taemin, Shah, Sumedh, Wadhwa, Harsh   +7 more
core