The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling [PDF]
, 2018 Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease
Antonelli, Manila +19 more
core +1 more source
Pineal region glioblastomas display features of diffuse midline and non-midline gliomas
Journal of Neuro-Oncology, 2018 Pineal region glioblastomas (GBM) are very rare, with approximately 46 cases described in the literature. The epidemiology, pathogenesis, and treatment of these lesions are poorly characterized.We identified all cases of pineal region GBM treated surgically at our institution between 1990 and 2017. Demographic and clinical follow-up data were extracted
Randy S, D'Amico +4 more
openaire +3 more sources
Diffusion-weighted MRI characteristics of the cerebral metastasis to brain boundary predicts patient outcomes. [PDF]
, 2014 DWI demonstrates changes in the tumor, across the tumor edge and in the peritumoral region which may not be visible on conventional MRI and this may be useful in predicting patient outcomes for operated cerebral ...
Bhojak, Maneesh +6 more
core +2 more sources
Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma [PDF]
, 2014 High-grade Brainstem Glioma (BSG), also known as Diffuse Intrinsic Pontine Glioma (DIPG), is an incurable pediatric brain cancer. Increasing evidence supports the existence of regional differences in gliomagenesis such that BSG is considered a distinct ...
Baker, Suzanne J. +7 more
core +3 more sources
Radiology Case ReportsDiffuse midline glioma (DMG), H3 K27-altered, is a newly defined “pediatric-type,” diffuse, high-grade glioma under current WHO classifications (updated in 2021).
Narushi Sugii, MD, PhD +4 more
doaj +1 more source
Procarbazine, CCNU and vincristine (PCV) versus temozolomide chemotherapy for patients with low-grade glioma: a systematic review. [PDF]
, 2018 Low-grade gliomas (LGG) encompass a heterogeneous group of tumors that are clinically, histologically and molecularly diverse. Treatment decisions for patients with LGG are directed toward improving upon the natural history while limiting treatment ...
Das, Sunit +4 more
core +1 more source
Intraoperative Consultations of Central Nervous System Tumors: A Review for Practicing Pathologists and Testing of an Algorithmic Approach. [PDF]
, 2019 Intraoperative consultations or frozen sections for central nervous system (CNS) tumors present a significant challenge for surgical pathologists because of their relative rarity and diversity.
Ding, Cristine +4 more
core
MoleculesDespite a specific histone mutation defining the unique genetic makeup, diffuse midline gliomas are heterogeneous tumors with a wide range of morphologic and molecular spectrum.
Ilwoo Park +2 more
doaj +1 more source
Immune Response following FLASH and Conventional Radiation in Diffuse Midline Glioma (DMG)
bioRxivPurpose Diffuse Midline Glioma (DMG) is a fatal tumor traditionally treated with radiotherapy (RT) and previously characterized as having a non-inflammatory tumor immune microenvironment (TIME).
O. Padilla +24 more
semanticscholar +1 more source
Spinal diffuse midline glioma: An unusual case presentation
South African Journal of OncologyPrimary spinal cord neoplasms are rare, accounting for 1% of paediatric central nervous system tumours. The majority of which are low-grade gliomas (LGG). A teenage male presented with rapidly progressive lower limb paralysis. He subsequently underwent a
Nadia Beringer +14 more
doaj +1 more source