Results 131 to 140 of about 25,184 (248)

Focused ultrasound-mediated blood–brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma

Journal of Translational Medicine
Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic strategies have been unsuccessful and radiotherapy (RT) remains the standard-of-care.
M. Tazhibi, N. McQuillan, Hong-Jian Wei, M. Gallitto, E. Bendau, Andrea Webster Carrion, X. Berg, D. Kokossis, Xu Zhang, Zhiguo Zhang, Chia-Ing Jan, A. Mintz, R. Gartrell, Hasan R. Syed, Adriana Fonseca, Jovana Pavisic, L. Szalontay, E. Konofagou, S. Zacharoulis, Cheng-Chia Wu   +19 more
semanticscholar   +1 more source

Pathology in Practice [PDF]

, 2017
Lofts, R, Priestnall, S L, Summers, B A, Terry, R   +3 more
core   +1 more source

Diffuse midline glioma with co⁃occurrence of H3 K27M and BRAF V600E mutations

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To explore the clinicopathological features, immunophenotype, molecular genetics, differential diagnosis and prognosis of diffuse midline glioma, H3 K27M mutant.
Nan WU, Xuan WANG, Xue WEI, Jin⁃rong WU, Ru⁃song ZHANG, Qun⁃li SHI, Nan⁃yun LI   +6 more
doaj  

Therapeutic strategies and management of desmoplastic infantile ganglioglioma: two case reports and literature overview [PDF]

, 2018
Introduction: Desmoplastic infantile gangliogliomas (DIG) are rare cerebral glioneural tumors usually occurring in early childhood. DIGs are generally benign although rare cases with poor outcome are known.
Avoledo, Pierino, Bächli, Heidi, Gratzl, Otmar, Tolnay, Marcus   +3 more
core  

Pediatric Diffuse Midline Glioma H3K27-Altered: From Developmental Origins to Therapeutic Challenges

Cancers
Simple Summary Diffuse midline glioma (DMG), especially diffuse intrinsic pontine glioma (DIPG), is a deadly pediatric brain tumor that is difficult to diagnose and lacks any real treatment.
Manuela Mandorino, Ahana Maitra, Domenico Armenise, O. Baldelli, Morena Miciaccia, S. Ferorelli, Maria Grazia Perrone, A. Scilimati   +7 more
semanticscholar   +1 more source

Objective Response to Radiation Therapy and Long-Term Survival of Patients with WHO Grade II Astrocytic Gliomas with Known LOH 1p/19q Status [PDF]

, 2018
Background:: WHO grade II gliomas are often approached by radiation therapy (RT). However, little is known about tumor response and its potential impact on long-term survival.
Arnold, Marlene, Curschmann, Jürgen, Deiana, Gianluca, Fathi, Ali-Reza, Mariani, Luigi, Reinert, Michael, Vajtai, Istvan, Vassella, Erik, Weis, Joachim   +8 more
core  

H3K27M neoepitope vaccination in diffuse midline glioma induces B and T cell responses across diverse HLA loci of a recovered patient

Science Advances
H3K27M, a driver mutation with T and B cell neoepitope characteristics, defines an aggressive subtype of diffuse glioma with poor survival. We functionally dissect the immune response of one patient treated with an H3K27M peptide vaccine who subsequently
T. Boschert, K. Kromer, Taga Lerner, K. Lindner, G. Haltenhof, C. L. Tan, K. Jähne, I. Poschke, L. Bunse, P. Eisele, N. Grassl, I. Mildenberger, K. Sahm, Michael Platten, J. Lindner, E. Green   +15 more
semanticscholar   +1 more source

Diffuse hemispheric glioma with H3 p.K28M (K27M) mutation: Unusual non-midline presentation of diffuse midline glioma, H3 K27M-altered?

Journal of Neuropathology and Experimental Neurology
Diffuse midline glioma, H3 K27-altered (DMG-H3 K27) is an aggressive group of diffuse gliomas that predominantly occurs in pediatric patients, involves midline structures, and displays loss of H3 p.K28me3 (K27me3) expression by immunohistochemistry and ...
K. Donev, Vanitha Sundararajan, Derek R Johnson, Jagadheshwar Balan, Meagan Chambers, Vera A Paulson, Kathryn P. Scherpelz, Zied Abdullaev, Martha Quezado, P. Cimino, Drew W Pratt, Ediel Valério, João Víctor Alves de Castro, D. Carraro, G. Torrezan, B. Wolff, L. Kulikowski, Felipe D'Almeida Costa, Kenneth J Aldape, Cristiane M Ida   +19 more
semanticscholar   +1 more source

BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma

Journal of Clinical Investigation
Diffuse midline glioma (DMG) H3K27-altered is one of the most malignant childhood cancers. Radiation therapy remains the only effective treatment yet provides a 5-year survival rate of only 1%.
Jun Watanabe, Matthew R Clutter, Michael J Gullette, Takahiro Sasaki, Eita Uchida, Savneet Kaur, Yan Mo, K. Abe, Yukitomo Ishi, Nozomu Takata, M. Natsumeda, Samantha Gadd, Zhiguo Zhang, Oren J. Becher, Rintaro Hashizume   +14 more
semanticscholar   +1 more source

Re-irradiation for progressive Diffuse Intrinsic Pontine Glioma (DIPG): The Spanish experience

EJC Paediatric Oncology
Introduction: Diffuse intrinsic pontine glioma (DIPG) is the most common malignant brainstem tumour in children. Despite advances in understanding its biology, current treatments have shown minimal impact on overall survival in this fatal disease.
Elena Panizo-Morgado, Felisa Vazquez-Gómez, Marta Perez-Somarriba, Miriam Pavon-Mengual, Andrés Morales-La Madrid, Blanca Lopez-Ibor, Palma Solano, Blanca Martinez de las Heras, Marta Cortés-Hernández, Miguel García-Ariza, Roberto Carlos Raynero-Mellado, Marta Martinez-Merino, Ana de Lucio Delgado, María Tallón-García, Carmen Garrido-Colino, Irene Ortiz-Gonzalez, Raquel Portugal, María Baro-Fernández, Carmen Gonzalez San-Segundo, Felipe Calvo, Alvaro Lassaletta   +20 more
doaj   +1 more source