Results 11 to 20 of about 25,184 (248)

Interdisciplinary care of children with diffuse midline glioma

Neoplasia: An International Journal for Oncology Research, 2023
Diffuse Midline Glioma (DMG) which includes Diffuse Intrinsic Pontine Glioma (DIPG) is an infiltrative tumor of the midline structures of the central nervous system that demonstrates an aggressive pattern of growth and has no known curative treatment. As
Christina Coleman, Katherine Chen, Alex Lu, Elizabeth Seashore, Schuyler Stoller, Taron Davis, Steve Braunstein, Nalin Gupta, Sabine Mueller   +8 more
doaj   +5 more sources

Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered. [PDF]

Front Oncol
Background As diffuse midline glioma, H3K27 altered, is a rare tumor entity with poor prognosis and few therapeutic options, only little is known so far about the genetic factors that influence tumorigenesis and the course of tumor development ...
Griessmair M, Delbridge C, Zimmer C, Mayr E, Wagner A, Canisius J, Metz MC, Wiestler B.   +7 more
europepmc   +2 more sources

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma [PDF]

Cell Reports
Summary: Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways. Previous studies
Stephanie M. Casillo, Taylor A. Gatesman, Akanksha Chilukuri, Srinidhi Varadharajan, Brenden J. Johnson, Daniel R. David Premkumar, Esther P. Jane, Tritan J. Plute, Robert F. Koncar, Ann-Catherine J. Stanton, Carlos A.O. Biagi-Junior, Callie S. Barber, Matthew E. Halbert, Brian J. Golbourn, Katharine Halligan, Andrea F. Cruz, Neveen M. Mansi, Allison Cheney, Steven J. Mullett, Clinton Van’t Land, Jennifer L. Perez, Max I. Myers, Nishant Agrawal, Joshua J. Michel, Yue-Fang Chang, Olena M. Vaske, Antony MichaelRaj, Frank S. Lieberman, James Felker, Sruti Shiva, Kelsey C. Bertrand, Nduka Amankulor, Costas G. Hadjipanayis, Kalil G. Abdullah, Pascal O. Zinn, Robert M. Friedlander, Taylor J. Abel, Javad Nazarian, Sriram Venneti, Mariella G. Filbin, Stacy L. Gelhaus, Stephen C. Mack, Ian F. Pollack, Sameer Agnihotri   +43 more
doaj   +2 more sources

A rare case of adult H3 K27-altered diffuse midline glioma with multifocal cerebrospinal fluid disseminated disease [PDF]

Radiology Case Reports
H3 K27-altered diffuse midline gliomas are a group of highly aggressive glial brain tumors that occur predominantly in children and carry a poor prognosis with limited treatment options.
Jackie Chen, BMedSc, MD, Samuel Conyngham, MBBS, Angela Bayly, MBBS, Jacqueline McMaster, BSci, BMed, Jason Trang, MBBS   +4 more
doaj   +2 more sources

Dual treatment with Val-083 and AZD1775 shows potent anti-tumor activity in diffuse midline glioma models. [PDF]

NPJ Precis Oncol
H3K27M diffuse midline gliomas (DMG) are characterized by p53 mutations and hypomethylation of MGMT, a DNA-repair enzyme, leading to resistance towards chemotherapeutic agents such as temozolomide (TMZ). As an alternative, we investigated the efficacy of
Subramaniam B, Roy D, Woldegerima A, Chong WC, Przystal JM, Zhang J, Laternser S, Kritzer B, Rangnath S, Knowles T, Yadavilli S, Packer R, Mueller S, Nazarian J.   +13 more
europepmc   +2 more sources

Diffuse midline glioma, H3K27-altered, mimicking central neurocytoma on MRI: A case report [PDF]

Radiology Case Reports
Diffuse midline glioma (DMG), H3K27-altered, is an aggressive central nervous system tumor that usually arises in midline structures such as the pons, thalamus, or spinal cord.
Yasuyuki Kojita, MD, PhD, Tomonori Kanda, MD, PhD, Shiho Yokoo, MD, Kazuki Yasuda, MD, Tokinosuke Miyazaki, MD, Feiya Zeng, MD, Naoe Jimbo, MD, PhD, Takashi Sasayama, MD, PhD, Takamichi Murakami, MD, PhD   +8 more
doaj   +2 more sources

Case Report: Application of <i>ex-vivo</i> drug sensitivity testing to identify personalized treatment options for an adolescent with diffuse midline glioma. [PDF]

Front Oncol
Diffuse midline glioma (DMG) is a pediatric brain cancer that has a dismal prognosis with limited treatment options. We present the treatment course and outcome of an adolescent male diagnosed with a thalamic DMG carrying a histone H3.3 K27M (H3K27M ...
Tan PK, Martins TJ, Becker PS, Wechsler-Reya RJ, Crawford JR.   +4 more
europepmc   +2 more sources

Diffuse midline glioma with H3-K27M mutation

Medicine, 2022
. Introduction:. Diffuse midline glioma with H3-K27M mutation is an infiltrative high-grade glioma, with predominantly astrocytic differentiation. Patient concerns:.
Yi-Hua Wang, Bachelor, Jian Gu, Master, Juan-Han Yu, MD, PhD, Lin Fu, MD, PhD, Qing-Chang Li, MD, PhD, Xue-Shan Qiu, MD, PhD, En-Hua Wang, MD, PhD   +6 more
doaj   +2 more sources

Disruption of ataxia telangiectasia-mutated kinase enhances radiation therapy efficacy in spatially directed diffuse midline glioma models. [PDF]

J Clin Invest
Diffuse midline gliomas (DMGs) are lethal brain tumors characterized by p53-inactivating mutations and oncohistone H3.3K27M mutations that rewire the cellular response to genotoxic stress.
Mangoli A, Valentine V, Maingi SM, Wu SR, Liu HQ, Aksu M, Jain V, Foreman BE, Regal JA, Weidenhammer LB, Stewart CE, Guerra Garcia ME, Hocke E, Abramson K, Michaeli TF, Williams NT, Luo L, Romero M, Deland K, Gadd S, Uchida E, Attardi L, Abe K, Hashizume R, Ashley DM, Becher OJ, Kirsch DG, Gregory SG, Reitman ZJ.   +28 more
europepmc   +2 more sources

Diffuse midline glioma, H3 K27M-mutant

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
DOI: 10.3969/j.issn.1672-6731.2017.12 ...
Xiao-ling YAN
doaj   +1 more source