Results 201 to 210 of about 25,184 (248)

Ara-C suppresses H3 K27–altered spinal cord diffuse midline glioma growth and enhances immune checkpoint blockade sensitivity

Science Advances
H3 K27–altered spinal cord diffuse midline glioma (H3-SCDMG) poses therapeutic challenges. Analysis of 73 clinical samples revealed heightened proliferation in H3-SCDMG versus wild-type tumors, suggesting therapeutic vulnerabilities.
Bo Pang, Yilin Wu, Songyuan An, Yuzhou Chang, Hao Yan, Han Lin, Zheng Zhao, Fan Wu, Q. Chang, Wenqing Jia, T. Jiang, Yongzhi Wang, R. Chai   +12 more
semanticscholar   +1 more source

GABAergic neuron-to-glioma synapses in diffuse midline gliomas

2022
AbstractPediatric high-grade gliomas are the leading cause of brain cancer-related death in children. High-grade gliomas include clinically and molecularly distinct subtypes that stratify by anatomical location into diffuse midline gliomas (DMG) such as diffuse intrinsic pontine glioma (DIPG) and hemispheric high-grade gliomas. Neuronal activity drives
Tara Barron, Belgin Yalçın, Aaron Mochizuki, Evan Cantor, Kiarash Shamardani, Dana Tlais, Andrea Franson, Samantha Lyons, Vilina Mehta, Samin Maleki Jahan, Kathryn R. Taylor, Michael B. Keough, Haojun Xu, Minhui Su, Michael A. Quezada, Pamelyn J Woo, Paul G. Fisher, Cynthia J. Campen, Sonia Partap, Carl Koschmann, Michelle Monje   +20 more
openaire   +1 more source

Diffuse midline glioma

2023
  +5 more sources

An Incidental Diffuse Midline Glioma Found at Autopsy

Journal of Forensic Sciences, 2017
AbstractThis case shows an unexpected midline glioma found at autopsy. Two siblings were riding on a single bicycle on the side of a road. The 13‐year‐old brother was seated and steering the bicycle, while the 14‐year‐old sister held onto the back. The bicycle veered left into traffic and was struck by a vehicle. The siblings were admitted to the local
Meggen, Walsh, William, Hamilton, Vektra, Casler, Anthony, Yachnis   +3 more
openaire   +2 more sources

CAR T cells for childhood diffuse midline gliomas

Nature Medicine, 2018
Anti-GD2 chimeric antigen receptor (CAR)-modified T cells may be a new and innovative approach for the treatment of pediatric H3-K27M-mutant diffuse midline gliomas.
Vijay Ramaswamy, Michael D Taylor
openaire   +2 more sources

A PROGNOSTIC HUMAN BRAIN NETWORK FOR DIFFUSE MIDLINE GLIOMA

Neuro-Oncology
Diffuse midline glioma (DMG) are near-universally lethal tumours of the paediatric central nervous system. In animal models, DMG form brain-wide, integrated networks through neuron-to-glioma synapses and glioma- to-glioma gap junctional coupling ...
J. Sidpra, Miss Valentina Lind, Alexander L Cohen, Frederic L. W. V. J. Schaper, Asthik Biswas, S. Sudhakar, Francisco Sepulveda, B. S. Peres, Thomas J Stone, Miss Cristina Alemán-Charlet, Miss Jiaqi Zhao, R. S. Opipari, Enrico De Vita, Deborah Ridout, S. Ferraciolli, Prof Leandro T Lucato, J. Avsenik, Eleonora Piccirilli, Andrés Morales, Jordi L Muchart, Maura E. Ryan, Rajan Patel, P. Haldipur, Marie T. Krüger, L. Zrinzo, A. Donson, K. Dorris, Prof Paul S Morgan, A. Mackay, Chris Jones, H. Venkatesh, A. Horn, Adam L. Green, Prof David M Mirsky, H. Akram, Kristian Aquilina, Kshitij Mankad, Michelle Monje, Prof Thomas S Jacques, Prof Michael D Fox, Darren Hargrave   +40 more
semanticscholar   +1 more source

Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma

bioRxiv
Diffuse midline glioma (DMG) is a near-universally lethal form of pediatric high-grade glioma, driven by neuronal activity-regulated paracrine signaling and synaptic integration of malignant cells into neural circuits.
Rebecca Mancusi, Eva Tatlock, Kiarash Shamardani, Lehi Acosta-Alvarez, Richard Drexler, Vrunda Trivedi, Avishai Gavish, Kouta Niizuma, Neeraj Soni, Pamelyn J. Woo, Sara B. Mulinyawe, S. Jahan, Natalie Logan, Karen Malacon, Youkyeong Gloria Byun, Anna C. Geraghty, Tara Barron, Kathryn R. Taylor, Michelle Monje   +18 more
semanticscholar   +1 more source

CNSC-11. DYSREGULATED MICROGLIAL SYNAPTIC ENGULFMENT IN DIFFUSE MIDLINE GLIOMA

Neuro-Oncology
Diffuse midline glioma (DMG) is a near-universally lethal form of pediatric high-grade glioma, driven by neuronal activity-regulated paracrine signaling and synaptic integration of malignant cells into neural circuits.
Rebecca Mancusi, M. Monje
semanticscholar   +1 more source

CNSC-68. LEVETIRACETAM THERAPEUTICALLY TARGETS GABAERGIC SYNAPSES IN DIFFUSE MIDLINE GLIOMA

Neuro-Oncology
Pediatric high-grade gliomas (HGGs) are the leading cause of brain cancer-related death in children. HGGs include distinct subtypes defined by anatomical location as well as molecular characteristics that stratify into H3K27M-altered diffuse midline ...
Tara Barron, Belgin Yalçın, Minhui Su, Aaron Mochizuki, Richard Drexler, Evan Cantor, Youkyeong Gloria Byun, Avishai Gavish, Kiarash Shamardani, Haojun Xu, Lijun Ni, Neeraj Soni, Dana Tlais, Andrea T. Franson, Samantha Lyons, V. Mehta, Yoon Seok Kim, Kathryn R. Taylor, Michael A. Quezada, Michael B. Keough, S. Jahan, Anna C. Geraghty, Rebecca Mancusi, L. T. Vo, Enrique Herrera Casteñeda, Pamelyn J. Woo, F. Ricklefs, U. Schüller, C. Petritsch, Hannes Vogel, Paul G. Fisher, C. Campen, S. Partap, Kai Kaila, C. Koschmann, M. Monje   +35 more
semanticscholar   +1 more source

Diffuse midline thalamic glioma – H3 K127M mutant

2020
Clinical History: A 37-year old man complaining since the last 3 months of progressive headaches, memory failure, sporadic vomiting and gait disturbances was admitted to the emergency department because of an acute onset of urinary incontinence. A brain CT was performed and showed a homogeneous isodense mass at the level of the third ventricle and left
Vercruysse, Vinciane, Rovira Cañellas, Alex   +1 more
openaire   +1 more source