Results 21 to 30 of about 25,184 (248)

Neuroimmune-competent human brain organoid model of diffuse midline glioma. [PDF]

Neuro Oncol
BACKGROUND Pediatric high-grade gliomas, such as diffuse midline glioma (DMG), have a poor prognosis and lack curative treatments. Current research models of DMG primarily rely on human DMG cell lines cultured in vitro or xenografted into the brains of ...
Sarnow K, Majercak E, Qurbonov Q, Cruzeiro GAV, Jeong D, Haque IA, Khalil A, Baird LC, Filbin MG, Tang X.   +9 more
europepmc   +2 more sources

Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma. [PDF]

Neuro Oncol
BACKGROUND Diffuse midline glioma (DMG) is the most aggressive primary brain tumor in children. All previous studies examining the role of systemic agents have failed to demonstrate a survival benefit; the only standard of care is radiation therapy (RT).
Gallitto M, Zhang X, De Los Santos G, Wei HJ, Fernández EC, Duan S, Sedor G, Yoh N, Kokossis D, Angel JC, Wang YF, White E, Kinslow CJ, Berg X, Tomassoni L, Zandkarimi F, Chio IIC, Canoll P, Bruce JN, Feldstein NA, Gartrell RD, Cheng SK, Garvin JH, Zacharoulis S, Wechsler-Reya RJ, Pavisic J, Califano A, Zhang Z, Wu CC.   +28 more
europepmc   +2 more sources

Combining the RCAS/tv-a retrovirus and CRISPR/Cas9 gene editing systems to generate primary mouse models of diffuse midline glioma

Neoplasia: An International Journal for Oncology Research
Diffuse midline gliomas (DMGs) are lethal brain tumors that arise in children and young adults, resulting in a median survival of less than two years.
Sophie R. Wu, Julianne Sharpe, Joshua Tolliver, Abigail J. Groth, Reid Chen, María E. Guerra García, Vennesa Valentine, Nerissa T. Williams, Sheeba Jacob, Zachary J. Reitman   +9 more
doaj   +2 more sources

Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries [PDF]

, 2018
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and ...
Antonelli, Manila, Antonelli, Manila, Bailey, Simon, Bartels, Ute, Baugh, Joshua, Benesch, Martin, Biassoni, Veronica, Bison, Brigitte, Boddaert, Nathalie, Bouffet, Eric, Broniscer, Alberto, Broxson, Emmett, Calmon, Raphael, Castel, David, Chaney, Brooklyn, Chintagumpala, Murali, Colditz, Niclas, Comito, Melanie, Dholaria, Hetal, Doughman, Renee, Drissi, Rachid, Foreman, Nicholas K., Fouladi, Maryam, Fuller, Christine, Gerber, Nicolas U., Giagnacovo, Marzia, Gielen, Gerrit H., Giraud, G´eraldine, Goldman, Stewart, Gottardo, Nicholas, Grill, Jacques, Grotzer, Michael A., Hargrave, Darren, Hassall, Timothy, Hawkins, Cynthia, Hoffman, Lindsey M., Hoffmann, Marion, Hulleman, Esther, Jabado, Nada, Jadrijevic Cvrlje, Filip, Jones, Blaise, Jones, Chris, Jones, David T. W., Kaspers, Gertjan J. L., Khatua, Soumen, Kieran, Mark W., Kramm, Christof M., Lane, Adam, Leach, James, Leary, Sarah, Massimino, Maura, Miles, Lili, Minturn, Jane, Modena, Piergiorgio, Nazarian, Javad, Packer, Roger, Pfaff, Elke, Pfister, Stefan M., Pietsch, Torsten, Puget, Stephanie, Sanchez, Esther, Shih, Chie-Schin, Solanki, Guirish A., Sophie Carret, Anne, Sturm, Dominik, van Vuurden, Dannis G., Vandertop, William P., Varlet, Pascale, Veldhuijzen van Zanten, Sophie E. M., von Bueren, Andr´e O., Warmuth-Metz, Monika, Warren, Katherine E., Yanez Escorza, Nancy, Ziegler, David S.   +73 more
core   +10 more sources

Diagnostic and therapeutical approaches to H3K27M-altered diffuse midline glioma in children: a review

Онкогематология, 2023
H3K27M-altered diffuse midline gliomas are the most devastating pediatric brain tumors. These tumors are characterized by lesion of central nervous system midline structures, diffuse infiltrative growth and fatal prognosis.
D. A. Morgacheva, D. A. Sitovskaia, Yu. V. Dinikina   +2 more
doaj   +1 more source

A case of diffuse midline glioma with histone H3 K27M mutation mimicking long segmental myelitis

Interdisciplinary Neurosurgery, 2021
Diffuse midline glioma with H3 K27M mutation is a new tumor entity from 2016 which is highly aggressive and classified as a WHO Grade IV tumor regardless of histopathologic features. We report a case of a 40-year-old male with diffuse midline glioma with
Hsin-Pin Lin, Cuiping Zhao, Vyas Viswanathan, Anthony T. Yachnis, James Wymer   +4 more
doaj   +1 more source

A case of adult-onset diffuse midline glioma diagnosed by histone H3K27M immunostaining after death, which required differentiation from brainstem encephalitis and myelitis [PDF]

, 2023
H3K27M-mutant diffuse midline glioma is a malignant glioma that was newly added to the World Health Organization classification in 2016. In diffuse midline glioma, the H3K27M-mutant sometimes develops sub-acutely and requires a differential diagnosis ...
Arakawa, Yoshiki, Ayaki, Takashi, Ikeda, Akio, Kuzuya, Akira, Minamiguchi, Sachiko, Mitsuhashi, Masahiro, Takahashi, Ryosuke, Togawa, Natsuko, Yamashita, Hirofumi   +8 more
core   +1 more source

H3 K27M-Altered Diffuse Midline Gliomas: A Review

Indian Journal of Neurosurgery, 2023
Diffuse midline glioma H3 K27M-altered is a recently renamed high-grade glioma in the 2021 World Health Organization (WHO) Classification of Central Nervous System Tumors, previously being labelled diffuse midline glioma H3 K27M-mutant in the 2016 update
Karol Wiśniewski, Andrew Ghaly, Kate Drummond, Andreas Fahlstrӧm   +3 more
doaj   +1 more source

A rare case of adult diffuse midline glioma with H3 K27M mutant in the prepontine cistern

Journal of International Medical Research, 2021
Diffuse midline glioma with the H3.3 histone A ( H3F3A ) or H3 clustered histone 2/3 ( HIST1H3B/C ) K27M mutation occurs primarily in children and less frequently in adults involving the midline structures of the central nervous system.
Xueling Chen, Ling Zhong, Jianwen Lin, Jian Yu   +3 more
doaj   +1 more source

Bridging the age gap: a review of molecularly informed treatments for glioma in adolescents and young adults

Frontiers in Oncology, 2023
Gliomas are the most common primary central nervous system (CNS) tumors and a major cause of cancer-related mortality in children (age <15 years), adolescents and young adults (AYA, ages 15–39 years), and adults (age >39 years). Molecular pathology
Annette Weiser, Annette Weiser, Astrid Sanchez Bergman, Charbel Machaalani, Julie Bennett, Julie Bennett, Patrick Roth, Regina R. Reimann, Javad Nazarian, Javad Nazarian, Ana S. Guerreiro Stucklin, Ana S. Guerreiro Stucklin   +11 more
doaj   +1 more source