Results 41 to 50 of about 25,184 (248)

Long-term follow-up of surgical resection alone for primary intracranial rostrotentorial tumors in dogs: 29 cases (2002-2013) [PDF]

, 2017
Intracranial neoplasia is frequently encountered in dogs. After a presumptive diagnosis of intracranial neoplasia is established based on history, clinical signs and advanced imaging characteristics, the decision to treat and which treatment to choose ...
Bastante, Alicia Rami, Feliu-Pascual, Alejandro Lujan, Font, Christina, Mascort, Joan, Pumarola, Marti, Sunol Iniesta, Anna   +5 more
core   +5 more sources

H3K27me3 in Diffuse Midline Glioma and Epithelial Ovarian Cancer: Opposing Epigenetic Changes Leading to the Same Poor Outcomes

Cells, 2022
Histone post-translational modifications modulate gene expression through epigenetic gene regulation. The core histone H3 family members, H3.1, H3.2, and H3.3, play a central role in epigenetics.
Charles A. Day, Edward H. Hinchcliffe, James P. Robinson   +2 more
doaj   +1 more source

Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas

Nature Communications, 2023
The spatial organisation of diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) remains to be investigated. Here, the authors integrate short-read and long-read spatial profiling of DMG and GBM to identify regulatory programs and cellular ...
Yanming Ren, Zongyao Huang, Lingling Zhou, Peng Xiao, Junwei Song, Ping He, Chuanxing Xie, Ran Zhou, Menghan Li, Xiangqun Dong, Qing Mao, Chao You, Jianguo Xu, Yanhui Liu, Zhigang Lan, Tiejun Zhang, Qi Gan, Yuan Yang, Tengyun Chen, Bowen Huang, Xiang Yang, Anqi Xiao, Yun Ou, Zhengzheng Su, Lu Chen, Yan Zhang, Yan Ju, Yuekang Zhang, Yuan Wang   +28 more
doaj   +1 more source

H3G34-Mutant Gliomas—A Review of Molecular Pathogenesis and Therapeutic Options

Biomedicines, 2023
The 2021 World Health Organization Classification of Tumors of the Central Nervous System reflected advances in understanding of the roles of oncohistones in gliomagenesis with the introduction of the H3.3-G34R/V mutant glioma to the already recognized ...
Anthony V. Nguyen, Jose M. Soto, Sarah-Marie Gonzalez, Jennifer Murillo, Eric R. Trumble, Frank Y. Shan, Jason H. Huang   +6 more
doaj   +1 more source

Brain networks under attack : robustness properties and the impact of lesions [PDF]

, 2016
A growing number of studies approach the brain as a complex network, the so-called ‘connectome’. Adopting this framework, we examine what types or extent of damage the brain can withstand—referred to as network ‘robustness’—and conversely, which kind of ...
Aerts, Hannelore, Caeyenberghs, Karen, Fias, Wim, Marinazzo, Daniele   +3 more
core   +2 more sources

H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant

Acta Neuropathologica Communications, 2020
Diffuse midline glioma, H3 K27M-mutant is a lethal brain tumor located in the thalamus, brain stem, or spinal cord. H3 K27M encoded by the mutation of a histone H3 gene such as H3F3A plays a pivotal role in the tumorigenesis of this type of glioma ...
Sachi Maeda, Fumiharu Ohka, Yusuke Okuno, Kosuke Aoki, Kazuya Motomura, Kazuhito Takeuchi, Hironao Kusakari, Nobuyuki Yanagisawa, Shinya Sato, Junya Yamaguchi, Kuniaki Tanahashi, Masaki Hirano, Akira Kato, Hiroyuki Shimizu, Yotaro Kitano, Shintaro Yamazaki, Shinji Yamashita, Hideo Takeshima, Keiko Shinjo, Yutaka Kondo, Toshihiko Wakabayashi, Atsushi Natsume   +21 more
doaj   +1 more source

Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma

Cell Reports, 2020
Summary: Histone 3 gene mutations are the eponymous drivers in diffuse midline gliomas (DMGs), aggressive pediatric brain cancers for which no curative therapy currently exists.
Nathan A. Dahl, Etienne Danis, Ilango Balakrishnan, Dong Wang, Angela Pierce, Faye M. Walker, Ahmed Gilani, Natalie J. Serkova, Krishna Madhavan, Susan Fosmire, Adam L. Green, Nicholas K. Foreman, Sujatha Venkataraman, Rajeev Vibhakar   +13 more
doaj   +1 more source

Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas

Scientific Reports, 2021
We evaluate the topographic distribution of diffuse midline gliomas and hemispheric high-grade gliomas in children with respect to their normal gene expression patterns and pathologic driver mutation patterns.
Eve Kazarian, Asher Marks, Jin Cui, Armine Darbinyan, Elizabeth Tong, Sabine Mueller, Soonmee Cha, Mariam S. Aboian   +7 more
doaj   +1 more source

Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma

Acta Neuropathologica Communications, 2017
Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectable.
Tina Y. Huang, Andrea Piunti, Rishi R. Lulla, Jin Qi, Craig M. Horbinski, Tadanori Tomita, C. David James, Ali Shilatifard, Amanda M. Saratsis   +8 more
doaj   +1 more source

A curious case of T2-FLAIR mismatch in H3K27M mutant glioma

Radiology Case Reports, 2022
Diffuse midline gliomas are a rare relatively new classification of primary central nervous system tumors which include astrocytomas, oligodendrogliomas, and glioblastomas.
William L. Valentino, MD, MS, Darren Okada, MD, Shiv Bhanu, MD   +2 more
doaj   +1 more source