Results 61 to 70 of about 25,184 (248)
Preclinical therapeutic targets in diffuse midline glioma
Drug Resistance Updates, 2019 Diffuse midline gliomas (DMG) are rapidly fatal tumors of the midbrain in children, characterized by a diffuse growing pattern and high levels of intrinsic resistance to therapy. The location of these tumors, residing behind the blood-brain barrier (BBB), and the limited knowledge about the biology of these tumors, has hindered the development of ...Meel, Michaël Hananja, Kaspers, Gertjan J. L., Hulleman, Esther +2 moreopenaire +3 more sourcesIntegrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. [PDF]
, 2017 We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases.Adam Resnick, Alan Mackay, Alexei N. Kisljakov, Andrew J. Martin, Andrew S. Moore, André O. von Bueren, Angel Montero Carcaboso, Angela J. Waanders, Anna Burford, Baker, Barrow, Bax, Bender, Bjerke, Bouffet, Buczkowicz, Cai, Cai, Carmen de Torres, Carvalho, Castel, Ceccarelli, Chan, Chris Jones, Christopher Chandler, Cynthia Hawkins, Darach Crimmins, David Castel, David T.W. Jones, Davis, Diana Carvalho, Dmitry M. Konovalov, Dorra H’mida-Ben Brahim, Elisa Izquierdo, Fontebasso, Fontebasso, Funato, Grasso, Hamid Nikbakht, Harry J. Han, Hennika, Henry C. Mandeville, Ho-Keung Ng, Jacques Grill, Janat Fazal-Salom, Jane Cryan, Jane Pears, Jaume Mora, John Caird, Jones, Jones, Jones, João N. Stavale, Kathryn R. Taylor, Khuong-Quang, Korshunov, Korshunov, Kramm, Kun Mu, Leslie R. Bridges, Louis, Lucas T. Bidinotto, Ludmila I. Shats, Lynley Marshall, Lynn Bjerke, Mara Vinci, Marie-Anne Debily, Mariona Sunol, Maryam Fouladi, Matthew Clarke, Meera Nandhabalan, Michael Baudis, Michael Farrell, Michelle Monje, Nada Jabado, Natacha Entz-Werle, Nicolaides, Northcott, Ofelia Cruz, Ostrom, Paugh, Paugh, Paugh, Pichai Raman, Puget, Qin, Richards, Rui M. Reis, Safa Al-Sarraj, Saoussen Trabelsi, Sara Temelso, Saumya Gupta, Schiffman, Schwartzentruber, Sergey Popov, Shlien, Stefan M. Pfister, Stergios Zacharoulis, Sturm, Sturm, Sucheta Vaidya, Suzanne J. Baker, Taylor, Taylor, Temime-Smaali, Temime-Smaali, Tiberi, Valeria Molinari, Venkatesh, Welcker, Wu, Wu, Wu, Xingang Li, Yada, Yang, Zarghooni +116 morecore +8 more sourcesThe landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
Nature Genetics, 2022 Single-cell RNA-seq and ATAC-seq, combined with spatial transcriptomics, identify age- and location-related cellular dynamics of diffuse midline gliomas, such as variable oligodendrocyte precursor-like tumor stem cell populations and increased ...Ilon Liu, Li Jiang, Erik R Samuelsson, Sergio Marco Salas, A. Beck, Olivia A Hack, Daeun Jeong, McKenzie L. Shaw, Bernhard Englinger, J. LaBelle, Hafsa M Mire, S. Madlener, L. Mayr, Michael A. Quezada, Maria C Trissal, E. Panditharatna, K. Ernst, J. Vogelzang, Taylor A. Gatesman, Matthew E. Halbert, Hana Palova, P. Pokorna, J. Štěrba, O. Slabý, R. Geyeregger, A. Diaz, Izac J. Findlay, Matthew D. Dun, A. Resnick, M. Suvà, David C. Jones, S. Agnihotri, J. Svedlund, C. Koschmann, C. Haberler, T. Czech, I. Slavc, Jennifer A. Cotter, K. Ligon, S. Alexandrescu, W. Yung, I. Arrillaga-Romany, J. Gojo, Michelle Monje, M. Nilsson, M. Filbin +45 moresemanticscholar +1 more sourceDevelopment of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods
This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou +14 morewiley +1 more sourceThe pontine diffuse midline glioma, EGFR‐subtype with ependymal features: Yet another face of diffuse midline glioma, H3K27‐altered
Brain Pathology, 2023 Diffuse midline glioma with two components: classical glial and ependymal.Tauziède-Espariat, Arnault, Métais, Alice, Mariet, Cassandra, Castel, David, Grill, Jacques, Saffroy, Raphaël, Hasty, Lauren, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Benichi, Sandro, Chrétien, Fabrice, Varlet, Pascale +11 moreopenaire +3 more sourcesNeuroradiological, genetic and clinical characteristics of histone H3 K27-mutant diffuse midline gliomas in the Kansai Molecular Diagnosis Network for CNS Tumors (Kansai Network): multicenter retrospective cohort
Acta Neuropathologica CommunicationsThis study aims to elucidate the clinical and molecular characteristics, treatment outcomes and prognostic factors of patients with histone H3 K27-mutant diffuse midline glioma.Nobuhide Hayashi, Junya Fukai, Hirokazu Nakatogawa, Hiroshi Kawaji, Ema Yoshioka, Yoshinori Kodama, Kosuke Nakajo, Takehiro Uda, Kentaro Naito, Noriyuki Kijima, Yoshiko Okita, Naoki Kagawa, Yoshinobu Takahashi, Naoya Hashimoto, Hideyuki Arita, Koji Takano, Daisuke Sakamoto, Tomoko Iida, Yoshiki Arakawa, Takeshi Kawauchi, Yukihiko Sonoda, Yuta Mitobe, Kenichi Ishibashi, Masahide Matsuda, Takamune Achiha, Takahiro Tomita, Masahiro Nonaka, Keijiro Hara, Noriyoshi Takebe, Takashi Tsuzuki, Yoshikazu Nakajima, Shiro Ohue, Nobuyuki Nakajima, Akira Watanabe, Akihiro Inoue, Masao Umegaki, Daisuke Kanematsu, Asako Katsuma, Miho Sumida, Tomoko Shofuda, Masayuki Mano, Manabu Kinoshita, Kanji Mori, Naoyuki Nakao, Yonehiro Kanemura +44 moredoaj +1 more sourceClinical protocol: Feasibility of evaluating abemaciclib neuropharmacokinetics of diffuse midline glioma using intratumoral microdialysis.
PLoS ONE, 2023 Diffuse midline gliomas (DMG) are the most aggressive brain tumors of childhood and young adults, with documented 2-year survival rates 10nmol/L, or tumor tissue studies demonstrate CDK inhibition, then restart of abemaciclib therapy along with ...Edjah K Nduom, John Glod, Desmond A Brown, Margaret Fagan, Mahalia Dalmage, John Heiss, Seth M Steinberg, Cody Peer, William D Figg, Sadhana Jackson +9 moredoaj +1 more sourceFirst-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma. [PDF]
, 2020 PurposeGDC-0084 is an oral, brain-penetrant small-molecule inhibitor of PI3K and mTOR. A first-in-human, phase I study was conducted in patients with recurrent high-grade glioma.Patients and methodsGDC-0084 was administered orally, once daily, to ...Cloughesy, Timothy F, Coimbra, Alexandre F, Ellingson, Benjamin M, Gerstner, Elizabeth, Lee, Eudocia Q, Lu, Xuyang, Morrissey, Kari M, Mueller, Lars U, Olivero, Alan G, Rodon, Jordi, Wen, Patrick Y, Wilson, Timothy R +11 morecore Efficient chemotherapy of rat glioblastoma using Doxorubicin-loaded PLGA nanoparticles with different stabilizers [PDF]
, 2011 Background: Chemotherapy of glioblastoma is largely ineffective as the blood-brain barrier (BBB) prevents entry of most anticancer agents into the brain.Bernreuther, Christian, Gelperina, S. E., Glatzel, Markus, Khalansky, Alexander S., Kreuter, Jörg (Prof. Dr.), Maksimenko, Olga, Wohlfart, Stefanie +6 morecore +3 more sources
