Results 81 to 90 of about 25,184 (248)

Fulminant leptomeningeal disease diagnosed as comutant H3F3A and FGFR diffuse midline glioma

Annals of Clinical and Translational Neurology
Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR diffuse midline glioma with a clinical presentation of fulminant leptomeningitis.
Larysa Benistant, Damien Reita, Maleka Schenck, Vincent Castelain, Hélène Cebula, Benoît Lhermitte, Laura Bender   +6 more
doaj   +1 more source

A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis

BMC Neurology, 2023
Background H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses. Case presentation We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with ...
A. Kaywan Aftahy, Vicki M. Butenschoen, Lisa Hoenikl, Friederike Liesche-Starnecker, Benedikt Wiestler, Friederike Schmidt-Graf, Bernhard Meyer, Jens Gempt   +7 more
doaj   +1 more source

The promise of metabolic imaging in diffuse midline glioma

Neoplasia: An International Journal for Oncology Research, 2023
Recent insights into histopathological and molecular subgroups of glioma have revolutionized the field of neuro-oncology by refining diagnostic categories. An emblematic example in pediatric neuro-oncology is the newly defined diffuse midline glioma (DMG)
Samantha Lovibond, Alexandra N. Gewirtz, Luca Pasquini, Simone Krebs, Maya S. Graham   +4 more
doaj   +1 more source

Development of the SIOPE DIPG network, registry and imaging repository : a collaborative effort to optimize research into a rare and lethal disease [PDF]

, 2017
Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival.
Bailey, S, Barkhof, F, Baugh, J, Biassoni, V, Bison, B, Calmon, R, Cannarozzo, A, Castel, D, Chaney, B, Colditz, N, Cruz, O, Damen-Korbijn, CM, De Jongh, D, De Wolf, R, Deak, L, Emmerik, J, Entz-Werle, N, Fouladi, M, Gandola, L, Garami, M, Gerber, N, Gielen, GH, Gil-da-Costa, MJ, Giraud, G, Grill, J, Grundy, R, Hargrave, DR, Hauser, P, Hayden, T, Hoffmann, M, Holm, S, Hulleman, E, Jacobs, S, Jadrijevic-Cvrlje, F, Janssens, GO, Jones, C, Jones, DT, Kaspers, GJ, Kattamis, A, Kebudi, R, Kitanovski, L, Kivivuori, SM, Kramm, CM, Leblond, P, Lieverst, JA, Lopez-Aguilar, E, Massimino, M, members of the SIOPE DIPG Network, ., Morales La Madrid, A, Noltes, J, Nysom, K, Pears, J, Pentikainen, V, Perek-Polnik, M, Rutkauskiene, G, Sanchez Aliaga, E, Shats, L, Slavc, I, Sturm, D, Sumerauer, D, Thorarinsdottir, HK, Torsvik, IK, Van Dijk, J, Van Gool, S, van Vuurden, DG, Vandertop, WP, Varlet, P, Veldhuijzen van Zanten, SE, von Bueren, AO, Warmuth-Metz, M, Zapata-Tarres, M, Zheludkova, O   +71 more
core   +5 more sources

An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene

Acta Neuropathologica Communications
Histone mutations (H3 K27M, H3 G34R/V) are molecular features defining subtypes of paediatric-type diffuse high-grade gliomas (HGG) (diffuse midline glioma (DMG), H3 K27-altered, diffuse hemispheric glioma (DHG), H3 G34-mutant).
Z. Reisz, R. Pereira, Smitha Nevis, A. Mackay, Leena Bhaw, Y. Grabovska, Ross Laxton, V. Molinari, A. Burford, Barnaby Clark, C. Bleil, B. Zebian, Erika Pace, Annette Weiser, Fernando Carceller, L. Marshall, Andrew King, Istvan Bodi, S. Al-Sarraj, Chris Jones, M. Clarke   +20 more
semanticscholar   +1 more source

Re-irradiation for children with diffuse intrinsic pontine glioma and diffuse midline glioma.

Radiotherapy and Oncology
Diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG) are incurable brain malignancies. In this study, we report one of the largest known single-institution cohorts of DIPG/DMG patients undergoing re-irradiation (RT2) to evaluate its effect on survival.Children aged less than 18 years treated for DIPG/DMG with initial fractionated ...
N. Shariff, Alejandro S. Moreno, Julie Bennett, Vijay Ramaswamy, Anirban Das, A. Liu, A. Huang, U. Tabori, Cynthia Hawkins, Peter Dirks, É. Bouffet, D. Keilty, B. Millar, David C. Hodgson, D. Tsang   +14 more
semanticscholar   +3 more sources

Immunohistochemistry as a tool for identifying EGFR amplification in CNS tumors

Brain Pathology, EarlyView.
EGFR gene amplification constitutes a diagnostic hallmark for glioblastoma, IDH‐wildtype (GB, IDH‐WT). Herein, we demonstrated that EGFR IHC is a highly specific and sensitive biomarker for identifying EGFR amplification and should be part of the neuropathologist's routine panel of antibodies.
Arnault Tauziède‐Espariat, Mary Bah, Farah Sassi, Noémie Pucelle, Charlotte Berthaud, Marion Mandoula, Zeina Dababou, Noah Carnes, Leïla Brissez, Lauren Hasty, Euphrasie Servant, Alice Métais, Pascale Varlet   +12 more
wiley   +1 more source

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas [PDF]

, 2013
The most common pediatric brain tumors are low-grade gliomas (LGGs). We used whole-genome sequencing to identify multiple new genetic alterations involving BRAF, RAF1, FGFR1, MYB, MYBL1 and genes with histone-related functions, including H3F3A and ATRX ...
A Gajjar, A Korshunov, A Lin, A McPherson, A Peraud, A von Deimling, AJ Sievert, AK Gnekow, B Tang, C Bettegowda, CG Mullighan, CG Mullighan, D Dias-Santagata, D Singh, D Sturm, DA Persons, DN Louis, DN Louis, DT Jones, DT Jones, DT Jones, DW Ellison, DW Parsons, E Bouffet, F Li, G Schindler, G Wu, GT Armstrong, H Cin, H Li, H Ohgaki, H Ohgaki, H Ohgaki, H Yan, I Qaddoumi, IF Pollack, IF Pollack, J Jonkers, J Schwartzentruber, J Wang, J Zhang, J Zhang, J Zhang, JE DeClue, JH Wisoff, JR Downing, KT Flaherty, M Katoh, M Ren, M Wang, MJ Ciesielski, MJ Riemenschneider, ML Bajenaru, MN Edmonson, N Turner, N Turner, ND Dees, PG Fisher, PJ Stephens, PK Duffner, R Endersby, R Listernick, R Listernick, RG Tatevossian, RG Tatevossian, RS Arora, S Pfister, S Yip, T Forshew, T Stokland, TE Merchant, V Rand, W Müller, WM Lin, Y Okamoto   +74 more
core   +1 more source

Integrated high‐resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34‐mutant reveals universal TP53 abnormalities

Brain Pathology, EarlyView.
This integrated high‐resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34‐mutant expands the spectrum of associated genetic changes and underscores the presence of universal TP53 abnormalities at copy number, sequence, and protein expression level, with frequent yet largely unrecognized TP53 copy‐neutral loss of ...
Jorge A. Trejo‐Lopez, Cinthya Zepeda Mendoza, Thomas M. Kollmeyer, Kristen L. Drucker, Vanessa M. Pazdernik, Paul A. Decker, Corinne E. Praska, Jayson Hardcastle, Stephanie Smoley, Matthew Isaacson, Mallika Gandham, Surendra Dasari, Aditya Raghunathan, Caterina Giannini, Gang Zheng, Aaron Wagner, M. Beatriz Lopes, Kar‐Ming A. Fung, JoElle G. Peterson, Andreana L. Rivera, Christopher Rossi, Meggen A. Walsh, Zied Abdullaev, Kenneth Aldape, Martha Quezado, Drew Pratt, Patrick Joseph Cimino, Robert B. Jenkins, Cristiane M. Ida   +28 more
wiley   +1 more source

Incidental findings of mass lesions on neuroimages in children [PDF]

, 2011
Increasing use of neuroimaging in children has led to more incidental findings of CNS mass lesions, the management of which is uncertain. The authors' aims in this study are to describe these mass lesions and their evolution, as well as to discuss the ...
Boltshauser, E, Grotzer, M A, Kellenberger, C J, Perret, C, Scheer, I   +4 more
core   +1 more source