Results 151 to 160 of about 30,233 (313)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Performance Enhancement of a Low-Pressure Ratio Centrifugal Compressor Stage with a Rotating Vaneless Diffuser by Impeller Disk Extended Shrouds

Journal of Applied Fluid Mechanics, 2016
Numerical simulations have been carried out to examine the performance and flow parameters of forced rotating vaneless diffuser obtained by the extension of impeller disks of a low-pressure ratio shrouded type centrifugal compressor stage with diffuser ...
S. Seralathan, D. G. Roy Chowdhury
doaj  

Experimental evaluation of the flow structure in a vertical conical diffuser with different air supply methods

Известия высших учебных заведений: Проблемы энергетики
RELEVANCE of the study is determined by the fact that vertical conical diffusers are used as auxiliary devices in many technical applications in various industries (chemical industry, power engineering, technological devices, etc.).THE PURPOSE.
L. V. Plotnikov, A. F. Ryzhkov, D. N. Krasilnikov, D. A. Davydov, V. A. Shurupov   +4 more
doaj   +1 more source

Unsteady Behavior of Diffuser Stall in a Centrifugal Compressor With Vaned Diffuser

, 2017
In this study, the unsteady behavior of a diffuser rotating stall in a centrifugal compressor with a vaned diffuser was investigated through experiments and numerical analyses.
Yutaka Ohta, Daiki Ema, Nobumichi Fujisawa   +2 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Comparative study on structural, electrical transport and magnetic properties of cr-doped in charge-ordered Pr0.75Na0.25Mn1-Xcrxo3 and Nd0.75Na0.25Mn1-Ycryo3 manganites

, 2018
Cr doping in charge-ordered Pr0.75Na0.25Mn1-xCrxO3 and Nd0.75Na0.25Mn1-yCryO3 have been synthesized using conventional solid-state method to investigate its effect on structural, electrical transport and magnetic properties.
Khairulzaman, Nurul Nasuha, Shamsuddin, Suhadir, Zawawi, Rabiatul Adawiyah, Ibrahim, Norazila   +3 more
core  

Analysis of Secondary Flow Behavior in Low Solidity Cascade Diffuser of a Centrifugal Blower (2nd Report, Effect of Blade Tip Groove near Leading Edge) [PDF]

, 2010
A low solidity cascade diffuser (LSD) shows features of a wide operating range and a high pressure ratio, however, a high level of noise. The first objective of the present study is to show that the noise can be reduced effectively without deterioration ...
村上, 天元, 坂口, 大作, 石田, 正弘, 植木, 弘信, 速水, 洋   +4 more
core  

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source