Results 91 to 100 of about 3,778,907 (367)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A microscopic approach to nonlinear Reaction-Diffusion: the case of morphogen gradient formation

, 2011
We develop a microscopic theory for reaction-difusion (R-D) processes based on a generalization of Einstein's master equation with a reactive term and we show how the mean field formulation leads to a generalized R-D equation with non-classical solutions.
Christopher Lutsko, J. D. Murray, James F. Lutsko, Jean Pierre Boon   +3 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Magnetism, FeS colloids, and Origins of Life

, 2010
A number of features of living systems: reversible interactions and weak bonds underlying motor-dynamics; gel-sol transitions; cellular connected fractal organization; asymmetry in interactions and organization; quantum coherent phenomena; to name some ...
A Ahniyaz, A Engel, A Etxeberria, A Nagya, A Preisinger, A Pross, A Yethiraj, AD Patel, AD Patel, AD Patel, AG Cairns-Smith, AJ Boyce, AJ Boyce, AL Buchachenko, AM Selvam, AM Tishin, AP Roberts, AS Keys, AY Zubarev, AY Zubarev, B-O Küppers, BA Grzybowski, C Bustamante, C Huber, C Jaryznski, C Tenailleau, C Viedma, CR Vestal, D Abel, D Abel, D Rickard, D Rickard, D Rickard, den Hollander WThF, DG Drubin, DI Khomskii, DJ Vaughan, DJ Vaughan, DL Stein, DS Kelley, E Schroedinger, EJ Milner-White, EJ Milner-White, ET Degens, EV Koonin, F Heylighen, FJ Dyson, FM Harold, G Mitra-Delmotte, G Nicolis, G Wächtershäuser, GL Früh-Green, GN Ling, GO Arrhenius, GS Engel, H Frohlich, H Frohlich, H Ohfuji, H Ohfuji, H Ohldag, HH Pattee, HH Pattee, HM Palmer, I Adler, I Kant, IK Kominis, J Al-Khalili, J Breivik, J Charnock, J Cheon, J Dyment, J Hemberger, J Higo, J Hoffmeyer, J Li, J McFadden, J Spitzer, J Torbet, JC Weaver, JD Bernal, JK Jain, JL Kirschvink, JL Kirschvink, JL Kirschvink, JM McBride, JP Ferris, JS Ban, JS Beard, JT Trevors, K Hatori, K Matsuno, K Righter, KA Michie, KM Doll, LE Orgel, LE Orgel, LE Orgel, LS Levitov, M Haw, M Jibu, M Mostovoy, M Polyani, M Winkelhofer, M Wolthers, M Wu, MF Chaplin, MF Chaplin, Mitra-Delmotte, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MO Goerbig, MP Pileni, NE Mavromatos, NJ Cerf, P Baaske, P Bak, P Galland, P Wasilewski, PCW Davies, PCW Davies, PCW Davies, PW Anderson, R Hazen, R Kopelman, R Lifshitz, R Palm, R Pastor-Satorras, R Phillips, R Shapiro, R Skomski, RA Dunlap, RCL Larter, RD Astumian, RD Astumian, RE Rosensweig, RT Wilkin, RW Chantrell, S Hagan, S Itoh, S Kauffman, S Lloyd, S Odenbach, S Sun, S Taketomi, S Traverso, SA Newman, T Schroeder, V Fritsch, V Hoffmann, VK Mer La, VM Goldschmidt, VN Manoharan, VTh Marteinsson, VV Korolev, W Cruz da, W Martin, W Martin, WH Zurek, Y Kwon, Y Lalatonne, Y Min, Z Merali, Z Sawlowicz, Z Sawlowicz, Z Wang   +172 more
core   +1 more source

Flexible couplings: diffusing neuromodulators and adaptive robotics [PDF]

, 2005
Recent years have seen the discovery of freely diffusing gaseous neurotransmitters, such as nitric oxide (NO), in biological nervous systems. A type of artificial neural network (ANN) inspired by such gaseous signaling, the GasNet, has previously been ...
Husbands, Phil, O'Shea, Michael, Philippides, Andy, Smith, Tom   +3 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Prediction equations for diffusing capacity (transfer factor) of lung for North Indians

Lung India, 2016
Background: Prediction equations for diffusing capacity of lung for carbon monoxide (DLCO), alveolar volume (VA), and DLCO/VA using the current standardization guidelines are not available for Indian population.
Sunil Kumar Chhabra, Rajeev Kumar, Uday A Gupta   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source