Results 121 to 130 of about 3,622,504 (385)

Implementing the Three-Equation Method of Measuring Single Breath Carbon Monoxide Diffusing Capacity

Canadian Respiratory Journal, 1996
Conventional methods of measuring the single breath diffusing capacity of the lung for carbon monoxide (DLcoSB) are based on the Krogh equation, which is valid only during breath holding.
Brian L Graham, Joseph T Mink, David J Cotton   +2 more
doaj   +1 more source

Uniqueness of diffusion operators and capacity estimates [PDF]

Journal of Evolution Equations, 2013
Let $ $ be a connected open subset of $\Ri^d$. We analyze $L_1$-uniqueness of real second-order partial differential operators $H=-\sum^d_{k,l=1}\partial_k\,c_{kl}\,\partial_l$ and $K=H+\sum^d_{k=1}c_k\,\partial_k+c_0$ on $ $ where $c_{kl}=c_{lk}\in W^{1,\infty}_{\rm loc}( ), c_k\in L_{\infty,{\rm loc}}( )$, $c_0\in L_{2,{\rm loc}}( )$ and $C(x)=(
openaire   +4 more sources

Optimal villi density for maximal oxygen uptake in the human placenta

, 2015
We present a stream-tube model of oxygen exchange inside a human placenta functional unit (a placentone). The effect of villi density on oxygen transfer efficiency is assessed by numerically solving the diffusion-convection equation in a 2D+1D geometry ...
Brownbill, P., Filoche, M., Grebenkov, D. S., Salafia, C., Serov, A. S.   +4 more
core   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Quantitative morphology of compensatory lung growth

European Respiratory Review, 2006
Compensatory lung growth is defined by the absolute increases in the quantity of functioning lung tissue in response to injury and/or disease, leading to a positive impact on functional outcome. The pneumonectomy model is used as an example to illustrate
C. C. W. Hsia
doaj  

Acute effects of combined exercise and oscillatory positive expiratory pressure therapy on sputum properties and lung diffusing capacity in cystic fibrosis: a randomized, controlled, crossover trial

BMC Pulmonary Medicine, 2018
Background Regular airway clearance by chest physiotherapy and/or exercise is critical to lung health in cystic fibrosis (CF). Combination of cycling exercise and chest physiotherapy using the Flutter® device on sputum properties has not yet been ...
Thomas Radtke, Lukas Böni, Peter Bohnacker, Marion Maggi-Beba, Peter Fischer, Susi Kriemler, Christian Benden, Holger Dressel   +7 more
doaj   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Degradation and healing in a generalized neo-Hookean solid due to infusion of a fluid

, 2010
The mechanical response and load bearing capacity of high performance polymer composites changes due to diffusion of a fluid, temperature, oxidation or the extent of the deformation.
A. Muliana, A.S. Wineman, A.S. Wineman, A.S. Wineman, A.V. Tobolsky, A.V. Tobolsky, C. Truesdell, G. Saccomandi, G.A. Kardomateas, H. Bouadi, H. Bouadi, H.E. Huntley, H.E. Huntley, H.E. Huntley, H.S. Hou, J.A. Shaw, J.B. McLeod, J.K. Knowles, J.M. Snead, J.P. Zhang, K. R. Rajagopal, K.R. Rajagopal, K.R. Rajagopal, K.R. Rajagopal, K.R. Rajagopal, K.R. Rajagopal, L. Tao, L.W. Cai, R. Chen, R.M. Christensen, S. Darbha, S. Roy, S.Y. Lee, Satish Karra, Y. Weitsman, Y. Weitsman   +35 more
core   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Skin thickness score as a surrogate marker of organ involvements in systemic sclerosis: a retrospective observational study

Arthritis Research & Therapy, 2019
Background Previous studies have shown the relationship between higher skin thickness score and the existence of organ involvements in systemic sclerosis (SSc).
Kazuki M. Matsuda, Ayumi Yoshizaki, Ai Kuzumi, Takemichi Fukasawa, Satoshi Ebata, Shunsuke Miura, Tetsuo Toyama, Asako Yoshizaki, Hayakazu Sumida, Yoshihide Asano, Koji Oba, Shinichi Sato   +11 more
doaj   +1 more source