Results 121 to 130 of about 107,316 (261)

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Diffusion-weighted magnetic resonance imaging of the pancreas: A narrative review. [PDF]

World J Radiol
Gao QY, Wang LJ, Ma C.
europepmc   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Cardiac-Gated Diffusion-Weighted Magnetic Resonance Imaging Assessment of Kidney Function in Patients With Kidney Cancer. [PDF]

Kidney Int Rep
Gilani N, Jeet N, Huang WC, Tatapudi VS, Deng FM, Friedman K, Soltys K, Bruno M, Kumbella M, Melamed ML, Charytan DM, Li X, Goldberg JD, Mikheev A, Nagpal S, Chandarana H, Sigmund EE.   +16 more
europepmc   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Diffusion-weighted magnetic resonance imaging as a promising technique for detection and follow-up of liver metastases from neuroendocrine tumors: a retrospective and prospective study from the NETTARE task force. [PDF]

J Endocrinol Invest
Feola T, Sesti F, Filice A, Nistor A, Valenti A, Puliani G, Centello R, Pandozzi C, Gagliardi A, Pirisino R, Bagni O, Salducci M, Appetecchia M, Catalano C, Isidori AM, Maccioni F, Giannetta E.   +16 more
europepmc   +1 more source

Mechanically Robust, Self‐Healable, and Cryotolerant GelMA Hydrogel for Wearable Tactile Sensors with Enhanced Durability, Lifetime, and Environmental Stability

Advanced Science, EarlyView.
A mechanically robust, self‐healable, moisturizing, cryotolerant and adhesive GelMA hydrogel is developed by incorporating polyvinyl alcohol, acrylic acid, sodium tetraborate, and glycerol into GelMA matrix via a photoinitiated polymerization process. The hydrogel‐derived omni‐healable ionotronic pressure sensor can sensitively and consistently monitor
Zhikang Li, Gengyu Han, Boqing Jia, Jijian Lu, Changxu Zhang, Bin Wang, Jiaxiang Wang, Kang Zhao, Muhammad Afzal Khan Qureshi, Lan Yu, Min Li, Guoxi Luo, Tong Wang, Qijing Lin, Weishi Li, Libo Zhao, Yumeng Xue   +16 more
wiley   +1 more source

Utility of Diffusion Weighted Magnetic Resonance Imaging in Early Detection and Staging of Acute Pancreatitis: Correlation with Revised Atlanta Classification [PDF]

Curr Med Imaging
Elkady RM, Bakr SH, Megally HI, Barakat IA, Alsharif W, Alhazmi FH, Elzaki M, Alshoabi SA, Alsaedi A, Gareeballah A, ELmaghraby M, Abbass WA.   +11 more
europepmc   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

An interim analysis of acute treatment adverse events and patient reported quality of life for functional imaging guided salivary gland sparing radiation therapy using diffusion-weighted magnetic resonance imaging. [PDF]

Phys Imaging Radiat Oncol
Cahill K, Hargrave C, Miller K, Leppien A, Chapple C, Meaghan J, Phan M, Denham M, O'Connor P, Ho A, Hogan D, Castelli J, Shan ZY, Min M.   +13 more
europepmc   +1 more source