Results 61 to 70 of about 2,118,011 (294)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

SiamDiff: A Diffusion-Driven Siamese Network for Scale-Aware Anti-UAV Tracking

Remote Sensing
Unmanned aerial vehicle (UAV) tracking faces significant challenges due to small targets and background interference. Traditional anchor-based tracking algorithms require designing numerous proposals to capture such tiny targets, which entails ...
Hong Zhang, Yihao Kuang, Jiaqi Wang, Lingyu Jin, Chang Xu, Yanda Meng, Bo Huang   +6 more
doaj   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Shift-Invariant Unsupervised Pansharpening Based on Diffusion Model

Remote Sensing
Pansharpening is a crucial topic in remote sensing, and numerous deep learning-based methods have recently been proposed to explore the potential of deep neural networks (DNNs).
Jialei Xie, Luyan Ji, Jinzhou Ye, Jilei Liu, Qi Feng, Kejian Liu, Yongchao Zhao   +6 more
doaj   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Probabilistic Diffusion Models Advance Extreme Flood Forecasting

Geophysical Research Letters
Extreme floods pose escalating risks in a changing climate, yet forecasting remains challenging due to peak flow underestimation and high uncertainty.
Zhigang Ou, Congyi Nai, Baoxiang Pan, Yi Zheng, Chaopeng Shen, Peishi Jiang, Xingcai Liu, Qiuhong Tang, Wenqing Li, Ming Pan   +9 more
doaj   +1 more source

Stepwise Attention Control for Training-Free Image Editing

IEEE Access
Text-conditioned image editing aims to modify visual content based on natural language prompts while preserving the spatial structure of the input image.
Geon-Chan Choi, Jong-Ki Han
doaj   +1 more source

Modelling diffusional transport in the interphase cell nucleus

, 2007
In this paper a lattice model for diffusional transport of particles in the interphase cell nucleus is proposed. Dense networks of chromatin fibers are created by three different methods: randomly distributed, non-interconnected obstacles, a random walk ...
Annika Wedemeier, Chen-Xu Wu, Holger Merlitz, Jörg Langowski, Lukacs G., Ptashne M., von Hippel P. H.   +6 more
core   +1 more source