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Diffusion-MRI in neurodegenerative disorders
Magnetic Resonance Imaging, 2015The ability to image the whole brain through ever more subtle and specific methods/contrasts has come to play a key role in understanding the basis of brain abnormalities in several diseases. In magnetic resonance imaging (MRI), "diffusion" (i.e. the random, thermally-induced displacements of water molecules over time) represents an extraordinarily ...
Joseph Goveas a +13 more
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Diffusion MRI in multiple sclerosis
Neurology, 2005Diffusion imaging is a quantitative, MR-based technique potentially useful for the study of multiple sclerosis (MS), due to its increased pathologic specificity over conventional MRI and its ability to assess in vivo the presence of tissue damage occurring outside T2-visible lesions, i.e., in the so-called normal-appearing white and gray matter.
Rovaris M +6 more
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2003
Although conventional T2-weighted magnetic resonance imaging (MRI) is sensitive for the detection of multiple sclerosis (MS) lesions, it is not without important limitations. First, MRI lacks specificity with regard to the heterogeneous pathological substrates of individual lesions, and in consequence does not allow tissue damage to be quantified ...
FILIPPI , MASSIMO, Rocca MA
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Although conventional T2-weighted magnetic resonance imaging (MRI) is sensitive for the detection of multiple sclerosis (MS) lesions, it is not without important limitations. First, MRI lacks specificity with regard to the heterogeneous pathological substrates of individual lesions, and in consequence does not allow tissue damage to be quantified ...
FILIPPI , MASSIMO, Rocca MA
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Diffusion of water in tissues and MRI
Magnetic Resonance in Medicine, 1991AbstractThe purpose of this paper is to present an overview of the diffusive behavior of water in biological tissues. The analysis shows that obstructive barriers would have to occupy very large volume fractions in order to account for the reduction in the diffusion coefficient (D) observed in biological systems.
H E Rorschach, Chen Lin, C F Hazlewood
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Journal of Magnetic Resonance - Series B, 1996
Quantitative-diffusion-tensor MRI consists of deriving and displaying parameters that resemble histological or physiological stains, i.e., that characterize intrinsic features of tissue microstructure and microdynamics. Specifically, these parameters are
P. Basser, C. Pierpaoli
semanticscholar +1 more source
Quantitative-diffusion-tensor MRI consists of deriving and displaying parameters that resemble histological or physiological stains, i.e., that characterize intrinsic features of tissue microstructure and microdynamics. Specifically, these parameters are
P. Basser, C. Pierpaoli
semanticscholar +1 more source
Anisotropy in diffusion‐weighted MRI
Magnetic Resonance in Medicine, 1991AbstractDiffusional anisotropy of water protons, induced by nonrandom, directional barriers which hinder or retard water motion, is measurable by MRI. Faster water diffusion was observed when the diffusion‐sensitizing gradient direction paralleled the long axes of white matter tracts, indicative of fewer bamers to water motion.
H S Asgari +3 more
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Diffusion MRI findings in phenylketonuria
European Radiology, 2003Two patients with phenylketonuria were studied who were under dietary control since infancy, and who were mentally normal. Diffusion MRI was obtained using a spin-echo, echo-planar sequence with a gradient strength of 30 mT/m at 1.5 T. A trace sequence (TR=5700 ms, and TE=139 ms) was used, acquired in 22 s.
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2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007
This paper presents a magnetic resonance imaging method that can provide high-resolution images characterizing water diffusion in biological tissues. These images contain information about tissue microstructure, thereby providing a useful means to monitor physiological changes.
Justin P. Haldar, Zhi-Pei Liang
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This paper presents a magnetic resonance imaging method that can provide high-resolution images characterizing water diffusion in biological tissues. These images contain information about tissue microstructure, thereby providing a useful means to monitor physiological changes.
Justin P. Haldar, Zhi-Pei Liang
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MRI and Diffusion MRI in nonparaneoplastic limbic encephalitis
Computerized Medical Imaging and Graphics, 2002This paper reports an 65-year-old woman with nonparaneoplastic limbic encephalitis. On MRI and diffusion MRI, diffuse and symmetrical, bilateral high-signal lesions were evident in the medial temporal lobes. The affected areas were hyperintense on b= 1000 s/mm(2) (heavily diffusion-weighted or true diffusion) images, a pattern similar to cytotoxic ...
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European Journal of Radiology Extra, 2003
Abstract Acute disseminated encephalomyelitis (ADEM) usually reveals patchy demyelinated lesions with high signal on T2-weighted sequences. Diffusion MRI in a 10-year-old patient with ADEM demonstrated two distinct lesion patterns occurring simultaneously in the cerebral white matter. These were a restricted diffusion pattern (high-signal on b =1000
Gökcay A. +3 more
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Abstract Acute disseminated encephalomyelitis (ADEM) usually reveals patchy demyelinated lesions with high signal on T2-weighted sequences. Diffusion MRI in a 10-year-old patient with ADEM demonstrated two distinct lesion patterns occurring simultaneously in the cerebral white matter. These were a restricted diffusion pattern (high-signal on b =1000
Gökcay A. +3 more
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