Results 31 to 40 of about 566,297 (301)

Transforming the practice of medicine through team science

Health Research Policy and Systems, 2020
Background The translation of biomedical research discoveries into clinical practice is marked by extended timelines (averaging 17 years) and multiple sequential process steps.
Jason H. Pitzen, Heidi L. Dieter, Darren L. Gronseth, Amber K. Dahl, Venessa L. Boyle, Tharana Maran, C. Michel Harper, Gregory J. Gores   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Diffusion Efficiency of Innovation among EU Member States: A Data Envelopment Analysis

Economies, 2019
Innovation, in contemporary times, has been established as the lynchpin of growth and national competitive advantage among countries. Supranational and national resources have jointly combined to create sound innovation strategies and diffusion policies ...
Henry Junior Anderson, Jan Stejskal
doaj   +1 more source

Keberhasilan Difusi Inovasi Gagasan Social Enterprise dalam Pemberdayaan Masyarakat Islam: Studi Komunitas Kampung Marketer Purbalingga

At-turas: Jurnal Studi Keislaman, 2021
Diffusion of innovation is an important part in the process of da'wah and empowerment of Islamic society. This article describes the strategies and success factors for the diffusion of innovation in the Islamic community empowerment programs implemented ...
Wahanani Mawasti
doaj   +1 more source

A framework for the adoption and diffusion of Personal Learning Environments in commercial organisations: an exploratory study in the learning and development sector in the UK [PDF]

, 2011
This study presents an exploratory approach to identify the main factors of Personal Learning Environment (PLE) adoption and diffusion within commercial organisations.
Chatterjee, Arunangsu, Law, Effie, Mikroyannidis, Alexander, Owen, Glyn, Velasco, Karen   +4 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Innovation diffusion process of higher education informatization based on Lotka-Volterra model.

PLoS ONE
In order to quantify the diffusion speed, influence scope and change trend of educational informatization innovation in colleges and universities, this paper studies the diffusion process of educational informatization innovation in colleges and ...
Junjuan Liu, Peiling Yan
doaj   +1 more source

A Dynamical Innovation Diffusion Model with Fuzzy Coefficient and Its Application to Local Telephone Diffusion in China

Discrete Dynamics in Nature and Society, 2013
This paper studies the innovation diffusion problem with the affection of urbanization, proposing a dynamical innovation diffusion model with fuzzy coefficient, and uses the shifting rate of people from rural areas stepping into urban areas to show the ...
Zhigao Liao, Jiuping Xu, Liming Yao
doaj   +1 more source

Unlocking Intersectoral Integration in Kazakhstan’s Agro-Industrial Complex: Technological Innovations, Knowledge Transfer, and Value Chain Governance as Predictors

Economies, 2023
The agro-industrial complex plays a vital role in driving economic growth and sustainable development. This study investigates the direct and indirect impact of technological innovations, knowledge transfer, and value chain governance on intersectoral ...
Turarova Aliya Manatovna, Nazym Esbergenovna Dabyltayeva, Elvira Abdulmitovna Ruziyeva, Gaukhar Sakhanova, Zhuldyz Maratovna Yelubayeva   +4 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source