Results 41 to 50 of about 159,662 (260)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Bank–Firm Common Ownership and Corporate Innovation Diffusion: Evidence from Risk-Buffering and Information-Risk Channels

Risks
Against the backdrop of China’s innovation-driven development strategy, innovation diffusion is a key stage through which firm-level innovation outcomes generate broader economic value.
Quan Li, Haodan Sun, Gaoya Song
doaj   +1 more source

Innovation and the Diffusion of Technology in Agriculture in Floodplains in the State of Amazonas

RAC: Revista de Administração Contemporânea, 2019
There is a vast literature on innovation and diffusion of technology in Agribusiness. The dominant explanation of dissemination of innovations emphasizes processes involving information flows through a social system.
Jonas Fernando Petry, Sabrina Arcanjo Sebastião, Erik Garcia Martins, Paulo Berti de Azevedo Barros   +3 more
doaj   +1 more source

Green innovation ecosystem evolution: Diffusion of positive green innovation game strategies on complex networks

Journal of Innovation & Knowledge
The essence of the evolution of the green innovation ecosystem is the process by which the positive strategy of green innovation spreads in a complex network.
Ren-Jie Zhang, H. Tai, Zheng-Xu Cao, Chia-Chen Wei, Kuo-Tai Cheng   +4 more
semanticscholar   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Innovation diffusion process of higher education informatization based on Lotka-Volterra model.

PLoS ONE
In order to quantify the diffusion speed, influence scope and change trend of educational informatization innovation in colleges and universities, this paper studies the diffusion process of educational informatization innovation in colleges and ...
Junjuan Liu, Peiling Yan
doaj   +1 more source

Transforming the practice of medicine through team science

Health Research Policy and Systems, 2020
Background The translation of biomedical research discoveries into clinical practice is marked by extended timelines (averaging 17 years) and multiple sequential process steps.
Jason H. Pitzen, Heidi L. Dieter, Darren L. Gronseth, Amber K. Dahl, Venessa L. Boyle, Tharana Maran, C. Michel Harper, Gregory J. Gores   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Dynamical Innovation Diffusion Model with Fuzzy Coefficient and Its Application to Local Telephone Diffusion in China

Discrete Dynamics in Nature and Society, 2013
This paper studies the innovation diffusion problem with the affection of urbanization, proposing a dynamical innovation diffusion model with fuzzy coefficient, and uses the shifting rate of people from rural areas stepping into urban areas to show the ...
Zhigao Liao, Jiuping Xu, Liming Yao
doaj   +1 more source