Results 61 to 70 of about 2,054,434 (283)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Creating the First Autonomous Systems of Internet in Siberia as a Spatial Diffusion of Innovations
Prostranstvennaâ ÈkonomikaThe spread of innovations affects the socio-economic development of regions, but the specifics of such a spread are not always clear. Contagious or hierarchical spatial diffusion is usually studied.
Viktor Ivanovich Blanutsa
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Salient Region Detection Using Diffusion Process with Nonlocal Connections
Applied Sciences, 2018 Diffusion-based salient region detection methods have gained great popularity. In most diffusion-based methods, the saliency values are ranked on 2-layer neighborhood graph by connecting each node to its neighboring nodes and the nodes sharing common ...
Huiyuan Luo +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mathematical Modelling and Analysis, 2008 A mathematical model for the diffusion process of ferromagnetic particles in a magnetic fluid is described. The unique solvability of the steady‐state particle concentration problem is investigated and an analytical expression for its solution is found ...
Viktor Polevikov, Lutz Tobiska
doaj +1 more source
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Effects of Water Absorption on the Insulating Properties of Polypropylene
EnergiesMoisture has been a crucial problem during the operation of cable systems. When we are faced with polypropylene (PP)-based insulation for the development of cable systems, there are few reports on the effects of water intrusion on the electrical ...
Rui Xi +8 more
doaj +1 more source