Results 71 to 80 of about 1,558,332 (335)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Original Music Album Diffusion Sustainability in Social Network-Based Communities: A Network Embedded Perspective

IEEE Access, 2020
An original music album is a collection of music created by an online musician, and is a special form of User Generated Content. This paper aims to identify the factors that drive original music album diffusion in online music community.
Genqiang Li, Renjing Liu
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Single-site approximation for reaction-diffusion processes

, 2006
We consider the branching and annihilating random walk $A\to 2A$ and $2A\to 0$ with reaction rates $\sigma$ and $\lambda$, respectively, and hopping rate $D$, and study the phase diagram in the $(\lambda/D,\sigma/D)$ plane.
G. Ódor, G. Ódor, H. Hinrichsen, H. J. Hilhorst, H. Takayasu, I. Jensen, J. L. Cardy, L. Canet, L. Canet, L. Canet, L. Peliti, M. Bramson, P. Grassberger, R. Dickman, U. C. Täuber   +14 more
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Template-Based Evaluation of Stable Diffusion via Attention Maps

Information
Text-to-image models such as Stable Diffusion (SD) require comprehensive, fine-grained, and high-precision methods for evaluating text–image alignment.
Haruno Fusa, Chonho Lee, Sakuei Onishi, Kanshin Fusa, Hiromitsu Shiina   +4 more
doaj   +1 more source

A Note on Estimation of Multi-Sigmoidal Gompertz Functions with Random Noise

Mathematics, 2019
The behaviour of many dynamic real phenomena shows different phases, with each one following a sigmoidal type pattern. This requires studying sigmoidal curves with more than one inflection point. In this work, a diffusion process is introduced whose mean
Patricia Román-Román, Juan José Serrano-Pérez, Francisco Torres-Ruiz   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Kinetic and Transport Equations for Localized Excitations in Sine-Gordon Model

, 1999
We analyze the kinetic behavior of localized excitations - solitons, breathers and phonons - in Sine-Gordon model. Collision integrals for all type of localized excitation collision processes are constructed, and the kinetic equations are derived.
C. S. Gardner, E. N. Economou, I. V. Baryakhtar, I. V. Baryakhtar, K. Sasaki, K. Z. Fesser, L. D. Faddeev, N. J. Zabusky, N. Theodorakopoulos, O. M. Braun, T. R. Koehier, V. E. Zakharov, V. E. Zakharov, V. G. Baryakhtar, V. G. Baryakhtar, Y. Wada   +15 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source