Results 111 to 120 of about 1,654,137 (372)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The importance of intravenous glucose tolerance test glucose stimulus for the evaluation of insulin secretion

Scientific Reports
For 100 years, the Intravenous glucose tolerance test (IVGTT) has been used extensively in researching the pathophysiology of diabetes mellitus and AIRg—the IVGTT-induced acute insulin response to the rapid rise in circulating glucose—is a key measure of
Ian F. Godsland, Desmond G. Johnston, KGMM Alberti, Nick Oliver   +3 more
doaj   +1 more source

Deciphering the microbiome–metabolome landscape of an inflammatory bowel disease inception cohort

Gut Microbes
The gut microbiota contribute to the etiopathogenesis of inflammatory bowel disease (IBD), but limitations of prior studies include the use of sequencing alone (restricting exploration of the contribution of microbiota functionality) and the recruitment ...
Shiva T. Radhakrishnan, Benjamin H. Mullish, Marton L. Olbei, Nathan P. Danckert, Maria A. Valdivia-Garcia, Jose I. Serrano-Contreras, Despoina Chrysostomou, Sharmili Balarajah, Robert W. Perry, John P. Thomas, Lejla Potari-Gul, Dezso Modos, Lucy C. Hicks, Nick Powell, Timothy R. Orchard, Jia V. Li, Julian R. Marchesi, Tamas Korcsmaros, James L. Alexander, Horace R. T. Williams   +19 more
doaj   +1 more source

Influence of Pre-Incubation of Inoculum with Biochar on Anaerobic Digestion Performance [PDF]

, 2023
Marvin T. Valentin, Kacper Świechowski, Andrzej Białowiec   +2 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Dietary total antioxidant capacity and risk of prediabetes and diabetes mellitus: a systematic review and dose-response meta-analysis of 170,919 participants

Frontiers in Nutrition
BackgroundObservational studies have assessed the association between total antioxidant capacity of the diet and risk of diabetes mellitus. However, results from these studies were not entirely consistent.
Ruomeng Li, Long Shu, Qin Zhu, Qin Zhu, Dan Lu   +4 more
doaj   +1 more source

Assessment of anaerobic co-digestion of food waste and wastewater solids for sustainable waste management in Yosemite National Park, USA [PDF]

, 2019
The growing need for sustainable municipal solid waste treatment and energy production has driven the development of new waste management methods like co-digestion.
Burmistrova, Julia
core  

Mesoscale modelling of polymer aggregate digestion

, 2019
We use mesoscale simulations to gain insight into the digestion of biopolymers by studying the break-up dynamics of polymer aggregates (boluses) bound by physical cross-links.
Doostmohammadi, Amin, Novev, Javor K., Yeomans, Julia M., Zöttl, Andreas   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Rheumatoid arthritis reprograms circadian output pathways

Arthritis Research & Therapy, 2019
Objective We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA). Methods We recruited adults (age 16–80 years old) with a clinical diagnosis of RA (active disease [DAS28 > 3.2]).
Toryn M. Poolman, Julie Gibbs, Amy L. Walker, Suzanna Dickson, Laura Farrell, James Hensman, Alexandra C. Kendall, Robert Maidstone, Stacey Warwood, Andrew Loudon, Magnus Rattray, Ian N. Bruce, Anna Nicolaou, David W. Ray   +13 more
doaj   +1 more source