Results 111 to 120 of about 1,350,953 (290)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
The prospect of artificial intelligence to personalize assisted reproductive technology
npj Digital MedicineInfertility affects 1-in-6 couples, with repeated intensive cycles of assisted reproductive technology (ART) required by many to achieve a desired live birth.
Simon Hanassab +9 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Frontiers in NutritionBackgroundAlthough studies have reported the associations between certain dietary patterns and the risk of Parkinson’s disease, these findings are limited and inconclusive.
Rong Zhang +4 more
doaj +1 more source
The effects of milk matrices on the transit and digestion of secretory immunoglobulin A in the gut : a thesis presented in partial fulfilment of requirements for the degree of Masters of Science in Animal Science at Massey University, Palmerston North, New Zealand and AgResearch, Ruakura, Hamilton, New Zealand [PDF]
, 2017 Figures 1-8 have been removed for copyright reasons, but may be accessed from their sources listed in the bibliographyBovine secretory immunoglobulin A (BSIgA) has the potential to provide protective effects to the gastrointestinal tract (GIT) when ...
O'Connor, Chrystal Te Ohorere
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FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Scientific ReportsInstantaneous, continuous, and reliable information on the molecular biology of surgical target tissue could significantly contribute to the precision, safety, and speed of the intervention.
Eftychios Manoli +6 more
doaj +1 more source
Fatty acid bioaccessibility and structural breakdown from in vitro digestion of almond particles. [PDF]
, 2019 Previous studies have shown that the size of almond particles influences lipid bioaccessibility during digestion. However, the extent of structural breakdown of almond particles during gastric digestion and its impact on lipid bioaccessibility is unclear.
Bornhorst, Gail M +3 more
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