Results 151 to 160 of about 1,654,137 (372)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Adherence to a priori and a posteriori dietary patterns and risk of Parkinson’s disease: a systematic review and meta-analysis of observational studies

Frontiers in Nutrition
BackgroundAlthough studies have reported the associations between certain dietary patterns and the risk of Parkinson’s disease, these findings are limited and inconclusive.
Rong Zhang, Long Shu, Qin Zhu, Qin Zhu, Nan Li   +4 more
doaj   +1 more source

Development of the laboratory anaerobic bioreactor for wet and dry digestion processes [PDF]

, 2016
This article presents partial results of the laboratory development of an anaerobic bioreactor designed for the physical modelling of (semi)continuous dry or wet anaerobic digestion processes.
Chamrádová, Kateřina, Kašáková, Kateřina, Rusín, Jiří   +2 more
core  

In Vitro Gastrointestinal Digestion Impact on the Antioxidant Activity of Extracts Produced from the Macroalgae Gracilaria gracilis and Ulva rigida [PDF]

, 2021
Sara A. Cunha, Paulo Nova, Ana Sofia Salsinha, Ana Gomes, Manuela Pintado   +4 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Influence of Wheat Straw Pelletizing and Inclusion Rate in Dry Rolled or Steam-flaked Corn-based Finishing Diets on Characteristics of Digestion for Feedlot Cattle. [PDF]

, 2016
Eight Holstein steers (216±48 kg body weight) fitted with ruminal and duodenal cannulas were used to evaluate effects of wheat straw processing (ground vs pelleted) at two straw inclusion rates (7% and 14%; dry matter basis) in dry rolled or steam-flaked
Calderon, JF, Chirino, JO, Gonzalez, VM, Manríquez, OM, Mendoza, GD, Montano, MF, Salinas-Chavira, J, Soto, S, Valdez, JA, Zinn, RA   +9 more
core  

Healthy and pro-inflammatory gut ecology plays a crucial role in the digestion and tolerance of a novel Gluten Friendly™ bread in celiac subjects: a randomized, double blind, placebo controlin vivostudy

, 2022
Angelo Andriulli, Antonio Bevilacqua, Orazio Palmieri, Anna Latiano, Rosanna Fontana, Domenica Gioffreda, Stefano Castellana, Tommaso Mazza, Anna Panza, Claudia Menzaghi, Elvira Grandone, Lazzaro Di Mauro, Ivana Decina, Michele Tricarico, Daniela Musaico, Markku Mäki, Jorma Isola, Alina Popp, Juha Taavela, Leonardo Petruzzi, Milena Sinigaglia, Maria Rosaria Corbo, Carmela Lamacchia   +22 more
openalex   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Human robotic surgery with intraoperative tissue identification using rapid evaporation ionisation mass spectrometry

Scientific Reports
Instantaneous, continuous, and reliable information on the molecular biology of surgical target tissue could significantly contribute to the precision, safety, and speed of the intervention.
Eftychios Manoli, James Higginson, Neil Tolley, Ara Darzi, James Kinross, Burak Temelkuran, Zoltan Takats   +6 more
doaj   +1 more source