Results 81 to 90 of about 903,842 (287)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The importance of intravenous glucose tolerance test glucose stimulus for the evaluation of insulin secretion

Scientific Reports
For 100 years, the Intravenous glucose tolerance test (IVGTT) has been used extensively in researching the pathophysiology of diabetes mellitus and AIRg—the IVGTT-induced acute insulin response to the rapid rise in circulating glucose—is a key measure of
Ian F. Godsland, Desmond G. Johnston, KGMM Alberti, Nick Oliver   +3 more
doaj   +1 more source

Dietary total antioxidant capacity and risk of prediabetes and diabetes mellitus: a systematic review and dose-response meta-analysis of 170,919 participants

Frontiers in Nutrition
BackgroundObservational studies have assessed the association between total antioxidant capacity of the diet and risk of diabetes mellitus. However, results from these studies were not entirely consistent.
Ruomeng Li, Long Shu, Qin Zhu, Qin Zhu, Dan Lu   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

COMPARISON OF DIGESTION METHODS APPLIED FOR LEAD QUANTIFICATION IN DRINKING WATER SAMPLES

, 2018
This study evaluated the digestion efficiency of a new rigorous digestion technique: focused shortwave infrared radiation digestion (SWIR). The increases of acid concentrations to 5% v/v and extended digestion time to 2h could increase lead recovery of ...
Zhang, Zewen
core  

Co-digestion of the mechanically recovered organic fraction of municipal solid waste with slaughterhouse wastes

, 2012
The current work aimed to resolve some long-standing questions about the potential benefits and limitations of co-digestion of slaughterhouse wastes.
Banks, C.J., Zhang, Y.
core   +1 more source

Algorithm-driven management of pediatric multiple magnetic foreign bodies: a single-center experience of 171 cases

BMC Pediatrics
Objective To delineate the clinical features of pediatric multiple magnetic foreign body ingestion and evaluate the clinical decision-making criteria for endoscopic, surgical, or conservative management. Methods A retrospective cohort study was conducted
Mengjun Dong, Kairui Yang, Hengpan Yao, Yijing Liu, Di Liu, Fang Zhou   +5 more
doaj   +1 more source

Rheumatoid arthritis reprograms circadian output pathways

Arthritis Research & Therapy, 2019
Objective We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA). Methods We recruited adults (age 16–80 years old) with a clinical diagnosis of RA (active disease [DAS28 > 3.2]).
Toryn M. Poolman, Julie Gibbs, Amy L. Walker, Suzanna Dickson, Laura Farrell, James Hensman, Alexandra C. Kendall, Robert Maidstone, Stacey Warwood, Andrew Loudon, Magnus Rattray, Ian N. Bruce, Anna Nicolaou, David W. Ray   +13 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

La biomasse pariétale des fourrages et sa valorisation par les herbivores

INRAE Productions Animales, 1990
Au sein de la biomasse végétale, les composés à teneur élevée en parois constituent une source d’aliments que seuls les herbivores peuvent utiliser. Parmi les herbivores, le Ruminant a été de loin le plus étudié.
J.M. BESLE, J.P. JOUANY
doaj   +1 more source