Results 41 to 50 of about 244,982 (129)

The Gold‐Maker of Animal Oil and Prussian Blue Fame — The Chemical and Medicinal Science Philosophy of Johann Conrad Dippel

open access: yesThe Chemical Record, EarlyView.
The radical Pietist Johann Conrad Dippel was a self‐proclaimed adept – a maker of gold and the philosophers’ stone. He was also a magister of theology, a doctor of medicine, and a self‐taught chemist, who coinvented the pigment Prussian Blue together with Johann von Diesbach, became known for his animal pyrolysis oil, his wonder‐wound balm, his ...
Curt Wentrup
wiley   +1 more source

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

open access: yesAdvanced Science, Volume 12, Issue 23, June 20, 2025.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang   +10 more
wiley   +1 more source

A Review of the Chemistry of Anaerobic Digestion: Methods of Accelerating and Optimizing Process Efficiency

open access: yesProcesses, 2019
The anaerobic digestion technology has been in existence for centuries and its underlying theory established for decades. It is considered a useful technology for the generation of renewable energy, and provides means to alleviate problems associated ...
A. Anukam   +3 more
semanticscholar   +1 more source

Bioprinted Patient‐Derived Organoid Arrays Capture Intrinsic and Extrinsic Tumor Features for Advanced Personalized Medicine

open access: yesAdvanced Science, Volume 12, Issue 20, May 29, 2025.
An embedded bioprinting enabled‐arrayed patient‐derived organoids (Eba‐PDO) platform that replicates intrinsic and extrinsic tumor characteristics is introduced. Eba‐PDOs more accurately mimic tissue than standard PDOs (Std‐PDOs) due to maturation in the tumor microenvironment.
Jonghyeuk Han   +15 more
wiley   +1 more source

Anti‐Inflammatory Macrophage‐Derived Exosomes Modified With Self‐Antigen Peptides for Treatment of Experimental Autoimmune Encephalomyelitis

open access: yesAdvanced Science, Volume 12, Issue 13, April 3, 2025.
Anti‐inflammatory macrophage‐derived exosomes modified with selfantigen peptides are developed to induce antigen‐specific immune tolerance. These exosomes demonstrate prophylactic effects in experimental autoimmune encephalomyelitis. Abstract Current treatments for autoimmune diseases often involve broad‐acting immunosuppressants, which carry risks ...
Qiaoyun Li   +5 more
wiley   +1 more source

Durable Muscle Extracellular Matrix Engineered with Adhesive Phenolic Moieties for Effective Skeletal Muscle Regeneration in Muscle Atrophy

open access: yesAdvanced Healthcare Materials, Volume 13, Issue 32, December 27, 2024.
Phenolic adhesive muscle extracellular matrix hydrogels with improved tissue adhesion, mechanical properties, and muscle‐specific cues are developed to treat muscle loss. These hydrogels facilitate muscle regeneration in disuse‐induced muscle atrophy and sarcopenia mouse models by generating enduring muscle‐like microenvironments for rejuvenating ...
Soojeong Choi   +5 more
wiley   +1 more source

Revealing the Mechanisms of Polyethylene Microplastics Affecting Anaerobic Digestion of Waste Activated Sludge.

open access: yesEnvironmental Science and Technology, 2019
Polyethylene (PE) microplastics retained in sewage sludge inevitably enter the anaerobic digestion system. To date, no information has been reported on the mechanisms of PE microplastics affecting anaerobic digestion of waste activated sludge (WAS). This
Wei Wei   +4 more
semanticscholar   +1 more source

High‐Efficiency, Prevascularization‐Free Macroencapsulation System for Subcutaneous Transplantation of Pancreatic Islets for Enhanced Diabetes Treatment

open access: yesAdvanced Materials, Volume 36, Issue 50, December 12, 2024.
A high‐efficiency, prevascularization‐free macroencapsulation system for the subcutaneous transplantation of pancreatic islets is developed. This novel system demonstrates excellent long‐term blood glucose control at the subcutaneous site, even with the transplantation of ≈250 IEQ of islets.
Seunggyu Jeon   +5 more
wiley   +1 more source

Human Placenta in Premodern Europe—a Cultural and Pharmaceutical Agent**

open access: yesBerichte zur Wissenschaftsgeschichte, Volume 47, Issue 4, Page 396-417, December 2024.
Abstract This paper was prompted by some striking similarities between both the ritual and the medical use of placenta in Ming China and in premodern Europe. Contrary to most accounts, which focus either on the rise of chemiatric medicine or on the growing interest in “exotic” substances, the seventeenth century in Europe also reveals a revived ...
Bettina Wahrig
wiley   +1 more source

Ultrafast enzymatic digestion of proteins by microdroplet mass spectrometry

open access: yesNature Communications, 2020
Enzymatic digestion for protein sequencing usually requires much time, and does not always result in high sequence coverage. Here we report the use of aqueous microdroplets to accelerate enzymatic reactions and, in particular, to improve protein ...
Xiaoqin Zhong, Hao Chen, R. Zare
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy