Results 101 to 110 of about 1,070,196 (253)
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Digestive enzyme profiles of spiny lobster Jasus edwardsii phyllosoma larvae
, 2004 Digestive enzyme activities of cultured (Stage I to VI) and wild (Stage V to XI) phyllosoma larvae of the spiny lobster Jasus edwardsii were investigated over progressive stages of development to provide an indication of their digestive capabilities and ...
Johnston, D (15497345) +3 more
core
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Mesocellular carbon foam with a bimodal structure and its use for enzyme immobilization
, 2005 1
김학성 +10 more
core
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
The Activity of Solanum tuberosum Leaf Extract and Chaconine in the Gut of Tenebrio molitor Larvae
ToxinsSteroidal glycoalkaloids (GAs) are key plant defense compounds, yet their effects on insect gut physiology are not fully understood. We investigated how purified α-chaconine and Solanum tuberosum leaf extract influence the gut function and growth of the ...
Malgorzata Slocinska +3 more
doaj +1 more source
, 2014 The present study aimed to contribute to the knowledge on the intraspecific variations of enzyme activities in populations of Calanus finmarchicus from different longitudes across the North Atlantic Ocean and their relation to changing environmental ...
Schmithüsen, Tosia +2 more
core +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Aquaculture ReportsWater temperature strongly influences metabolic rate, digestive physiology, and nutrient utilization in poikilothermic aquatic species such as shrimp.
Benjamin Castro +4 more
doaj +1 more source