In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong +11 more
wiley +1 more source
Effects of Ivy (<i>Hedera helix</i>) Leaf Extract on Growth, Digestive Enzyme Activity, Hematological Parameters, Innate Immunity, and the Expression of Immune-Related Genes in Rainbow Trout (<i>Oncorhynchus mykiss</i>). [PDF]
Fadaei R +4 more
europepmc +1 more source
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo +40 more
wiley +1 more source
Effect of Different Opening Diet on the Growth, the Structure of the Digestive Tract and Digestive Enzyme Activity of Larval and Juvenile Mystus macropterus. [PDF]
Li X +6 more
europepmc +1 more source
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti +11 more
wiley +1 more source
Effect of Dietary Supplementation with Red-Fleshed Dragon Fruit (<i>Hylocereus polyrhizus</i>) Juice By-Product Extract (HJBE) on Growth Performance, Digestive Enzyme Activity, Antioxidant Status, Immune Parameters, and Disease Resistance Against <i>Edwardsiella tarda</i> in Juvenile Red Seabream (<i>Pagrus major</i>). [PDF]
Kang DY +6 more
europepmc +1 more source
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai +13 more
wiley +1 more source
Potassium diformate affects the growth and development of broilers by improving intestinal function and digestive enzyme activity. [PDF]
Chen X +7 more
europepmc +1 more source

