Results 171 to 180 of about 232,595 (310)

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Effect of dietary biochar supplementation on growth, blood constituents, digestive enzymes, intestinal microbiota and viscosity, antioxidant indices, and carcass traits of broiler chicks. [PDF]

Trop Anim Health Prod
Emam AM, Elnesr SS, Mahmoud BY, El-Full EA, Abdel-Kader IA, Semida DA.   +5 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Investigation of the potential of phytochemicals derived from citrus peels to inhibit digestive enzymes: an overture to the management of lifestyle diseases. [PDF]

J Enzyme Inhib Med Chem
Moloi L, Samson S, Tshiyoyo K, Maluleke K, Oberholzer M, Baloyi I, Malgas S.   +6 more
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Comparative and combined effects of in ovo probiotic injection and early feeding on growth development, intestinal morphology, ileum microbiota, digestive enzymes, and immune responses in broiler chickens. [PDF]

Poult Sci
Hassanlou A, Khalilzadeh S, Sadat-Hosseini B, Hassani R, Ebrahimi M.   +4 more
europepmc   +1 more source

Temperature- and Diet-Induced Plasticity of Growth and Digestive Enzymes Activity in Spongy Moth Larvae. [PDF]

Biomolecules, 2023
Lazarević J, Milanović S, Šešlija Jovanović D, Janković-Tomanić M.   +3 more
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Modulation of intestinal transport of nutrients following dietary exposure to Fusarium mycotoxins in broiler chickens [PDF]

, 2014
Antonissen, Gunther, Croubels, Siska, Ducatelle, Richard, Haesebrouck, Freddy, Hessenberger, Sabine, Martel, An, Pasmans, Frank, Su, Shengchen, Van Immerseel, Filip, Verlinden, Marc, Wong, Eric   +10 more
core   +1 more source

Assessing the effect of Bacillus rugosus NM007 as a novel probiotic strain on growth performance, hemato-biochemical profile, immune response, digestive enzymes and intestinal histomorphology of Nile tilapia (Oreochromis niloticus). [PDF]

World J Microbiol Biotechnol
Shokrak NM, Bakr BA, Tawfik S, Mohamed RA, Abdella B.   +4 more
europepmc   +1 more source