Results 91 to 100 of about 735,084 (311)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Impact of bacteria and yeast with probiotic properties on performance, digestibility, health status and gut environment of growing pigs in Vietnam [PDF]

, 2010
This thesis aimed to evaluate the effects of six lactic acid bacteria (LAB) strains and Bacillus subtilis H4, Saccharomyces boulardii Sb, and a microbial enzyme mixture, supplemented to basal diets on the performance, diet digestibility, health status ...
Giang, Hoang Huong
core  

Digestive and locomotor capacity show opposing responses to changing food availability in an ambush predatory fish [PDF]

, 2018
Metabolic rates vary widely within species, but little is known about how variation in the “floor” (i.e. standard metabolic rate in ectotherms; SMR) and “ceiling” (maximum metabolic rate; MMR) for an individual's aerobic scope (AS) are linked with the ...
Ali, Auer, Auer, Bartoń, Bates, Bell, Biro, Biro, Boos, Brett, Burton, Careau, Careau, Careau, Chabot, Claireaux, Clark, Fisher, Fry, Fu, Fu, Fu, Halsey, Hervant, Hopkins, Jain, Kern, Killen, Killen, Killen, Killen, Killen, Killen, Killen, Killen, Killen, Lande, Lee, Marras, Marras, Martínez, Martínez, McCue, Metcalfe, Millidine, Méndez, Nakagawa, Nakagawa, Nelson, Nicieza, Norin, Norin, Norin, Norin, Norin, O'Connor, Pang, Post, Rosenfeld, Royle, Secor, Van Leeuwen, Wang, Xie, Yan, Yang, Zeng, Álvarez   +67 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The nose and tongue as chemical detectors

, 2005
Human chemical senses are the gatekeepers of our digestive system. Chemical separation combined with human sensory perception has been used to isolate and identify a natural non-steroidal anti-inflammatory compound in olive oil.
Keast, Russell
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Protocadherin 1 (PCDH1) Promotes Pancreatic Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition (EMT) Progression Through the NF-κB Pathway

Cancer Management and Research
JianXin Lv, Jie Lou, Shaoqing Ding, QuanHua Ding, LingJia Sun, YouPing Zhang Digestive System Department, NingBo No.2 Hospital, Ningbo, Zhejiang, People’s Republic of ChinaCorrespondence: YouPing Zhang, Digestive System Department, NingBo No.2 Hospital ...
Lv J, Lou J, Ding S, Ding Q, Sun L, Zhang Y   +5 more
doaj  

Is intra-abdominal hypertension a missing factor that drives multiple organ dysfunction syndrome? [PDF]

, 2014
In a recent issue of Critical Care, Cheng and colleagues conducted a rabbit model study that demonstrated that intra-abdominal hypertension (IAH) may damage both gut anatomy and function. With only 6 hours of IAH at 25 mmHg, these authors observed an 80%
De Waele, Jan, Kirkpatrick, Andrew W, Laupland, Kevin, Roberts, Derek J   +3 more
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Development of esophagogastroduodenoscopy in China: results from the national census in 2013 and 2020

Frontiers in Oncology
BackgroundGiven the significant burden of upper digestive diseases, there has been a substantial increase in the utilization of esophagogastroduodenoscopy (EGD) in China from 2012 to 2019.
Siwei Zhou, Siwei Zhou, Zheran Chen, Zheran Chen, Yunfei Jiao, Yunfei Jiao, Zhiyuan Cheng, Zhiyuan Cheng, Zhiyuan Cheng, Ye Gao, Ye Gao, Tianjiao Wang, Tianjiao Wang, Lei Xin, Lei Xin, Rong Wan, Luowei Wang, Luowei Wang   +17 more
doaj   +1 more source