Results 111 to 120 of about 17,737,377 (302)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Microflora of human digestive system.

, 2010
Lidský trávicí systém je fyziologicky osídlen mnoha mikroorganismy. Toto osídlení je značně individuální a vyvíjí se v průběhu života a také vlivem vnějších podmínek.
Adamcová, Gabriela
core   +2 more sources

Digestive system: Pancreas (OckHS-577)

, 1964
Digestive system: Pancreas -- Pancreas -- Nervous tissue -- Exocrine cells visibleStain: Hematoxylin and ...
Ockerman, Herbert W.
core   +1 more source

Urgent revascularization of a liver allograft with a saphenous vein interposition graft between the hepatic artery and the recipient splenic artery after late hepatic artery thrombosis

, 2005
Digestive Diseases and Sciences, Vol. 50, No. 6 (June 2005), pp. 1177–1180 ( C 2005)Hepatic artery thrombosis (HAT) after liver transplantation is a severe complication which may lead to graft infarction and subsequent graft loss. It complicates 2–12%
Işık, Burak, Söğütlü, Gökhan, Yılmaz, Sezai, Ara, Cengiz, Battaloğlu, Bektaş, Yılmaz, Mehmet, Kıvrımoğlu,Hale S., Kıvrımoğlu, Vedat   +7 more
core  

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer

Journal of Experimental & Clinical Cancer Research
Background Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and treatment options for advanced CRC are limited. The regulatory mechanisms of aberrant NAT10-mediated N4-acetylcytidine (ac4C) modifications in cancer ...
Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An   +12 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Neuroendocrine Neoplasms of the Digestive System

The digestive system represents the most common localization for neuroendocrine neoplasms (NEN) in the human body. Despite a common classification and some unifying characteristics, for example the tissue and serum markers used for their identification ...
Schott M., Knoefel W. T., Anlauf M., Jesinghaus M., Uccella S., Roderburg C., Kloppel G., La Rosa S., Luchini C., Dromain C., Haberle L., Konukiewitz B., Marinoni I., Pulvirenti A., Jann H., Giesel F. L., Antonini P., Esposito I., Kasajima A., Perren A., Sipos B., Dizdar L., Novruzov E., Mattes-Gyorgy K., Villard N., Boeck I., Pea A.   +26 more
core   +2 more sources