Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
An Economic Analysis of a Dairy Anaerobic Digestion (A.D.) System: Will Dairy Producers Invest in A.D. Technology to Reduce Potential Litigation Suits? [PDF]
In many areas of the United States, dairy and livestock farmers are facing lawsuits due to a variety of externalities, such as odor and other forms of non-point source pollution, caused by Confined animal feeding operations (CAFO's).
Davis, Brandon L.
core +1 more source
Experimental immunology<br>Distribution of the type I interferon in different organs of chicken digestive system [PDF]
, 2014 Shuyuan Guo +4 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Frontiers in ImmunologyBackgroundImmune checkpoint inhibitors (ICIs) represent a paradigm shift in the development of cancer therapy. However, the improved efficacy of ICIs remains to be further investigated.
Tianrui Kuang +11 more
doaj +1 more source
Clustering of Molecular Alterations in Gastroesophageal Carcinomas
Neoplasia: An International Journal for Oncology Research, 2004 Gene expression levels are regulated at many levels. Integration of genome-wide analyses for the study of DNA and RNA provides a unique tool to detect genetic alterations in the cancer genome.
Natalie Koon +6 more
doaj +1 more source
Validitas Media Gambar Dengan Aplikasi Movie Maker Pada Materi Sistem Pencernaan Manusia Untuk Tingkat SMP [PDF]
, 2016 The result of research interviews with biology teacher at SMPN 2 Sungai Limau, Padang- Pariaman district revealed that, when the teacher explains the material in human digestive system, teachers only explain lessons using media board.
Susanti, D. (Diana)
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
PCR-based molecular characterization of Blastocystis hominis subtypes in southwest of Iran
Journal of Infection and Public Health, 2018 Blastocystis hominis is the most common intestinal parasite found in humans and many other hosts. Pathogenicity of Blastocystis sp. remains controversial and it has been suggested that it may be associated with certain subtypes of organism.
Shahram Khademvatan +6 more
doaj +1 more source