Results 181 to 190 of about 17,737,377 (302)

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Role of cuproptosis in digestive system tumors (Review). [PDF]

Int J Mol Med
Zhang L, Cheng Y, Tang L, Zhu J, Tuo B.
europepmc   +1 more source

Leaftronics: Bio‐Fractal Scaffolds From Leaf Venation for Low‐Waste Electronics

Advanced Materials, EarlyView.
“Leaftronics” transforms naturally evolved leaf venation into quasi‐fractal scaffolds for sustainable electronics. Polymer‐infiltrated leaf skeletons can be used to fabricate ultra‐smooth, reflow‐ and thin‐film‐compatible decomposable substrates, while making the same lignocellulose networks conducting results in flexible transparent electrodes.
Rakesh Rajendran Nair, Hrisheekesh Thachoth Chandran, Karl Leo, Hans Kleemann   +3 more
wiley   +1 more source

Characterization of dysbiosis patterns in gut microbiota of digestive system cancers: an umbrella review. [PDF]

Front Microbiol
Wang J, Liu Y, Yu Y, Chen X, Chen G, Chen Y, Chen X, Liu S.   +7 more
europepmc   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Chemoresistance in the era of immunotherapy: challenges and novel combinatorial strategies for digestive system tumors. [PDF]

Front Immunol
Yang L, Zhou D, Cao K, Mao D, Wang C, Wei T, Deng Y, Yi Z, Li W, Chen Z.   +9 more
europepmc   +1 more source

Programmable Functional Silicification of DNA Origami Nanostructures

Advanced Materials, EarlyView.
This work introduces additional functionality into silica‐coated DNA origami nanostructures using non‐standard silica precursors. A fluorescent precursor enables enhanced intracellular tracking, while a disulfide‐containing reagent yields redox‐responsive, degradable silica coatings.
Anna V. Baptist, Lasse Guericke, Philipp Mauker, Oliver Thorn‐Seshold, Amelie Heuer‐Jungemann   +4 more
wiley   +1 more source

Mortality trends in digestive system malignancies among US adults aged 45 years or older, 1999 to 2023: A CDC WONDER time-trend analysis. [PDF]

Medicine (Baltimore)
Huang S, Wang X, Xu C.
europepmc   +1 more source

Transient Cytoskeletal Anisotropy Encodes Short‐Term Mechanical Memory in Glioblastoma Cells

Advanced Materials, EarlyView.
The same mechanical deformation can produce distinct cytoskeletal states depending on loading history. Experiments and constitutive modeling reveal that transient actin–vimentin anisotropy stores mechanical information and governs short‐term mechanical memory in glioblastoma cells.
Clara Gomez‐Cruz, Matthieu Gelin, Lucas Pradeau‐Phélut, Arrate Muñoz‐Barrutia, Sandrine Etienne‐Manneville, Daniel Garcia‐Gonzalez   +5 more
wiley   +1 more source

Organ-Specific Cancer-Associated Fibroblast Subtypes Across the Digestive System Linked to Cancer Hallmarks. [PDF]

Cancer Sci
Wang H, Semba T, Yonemura A, Naito H, Fu L, Tajiri T, Iwatsuki M, Ishimoto T.   +7 more
europepmc   +1 more source