The substrate of the biopsychosocial influences in the carcinogenesis of the digestive tract
Journal of Mind and Medical Sciences, 2016 Digestive cancer represents a severe public health problem, being one of the main causes of death. It is considered a multifactorial disease, with hereditary predisposition, environmental factors, and other factors involved in carcinogenesis.
Georgică C. Târtea +5 more
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Causes of hospitalization of elderly residents in a city of Paraná, an analysis of the last 5 years
Revista de Enfermagem da Universidade Federal de Santa Maria, 2011 The research objective was to describe the profile of hospital morbidity and mortality of elderly residents in Guarapuava/PR, by sex and age in the last five years.
Calíope Pilger +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Epidemiological aspects of morbidity in the class of digestive organs in Kazakhstan [PDF]
Терапевтический архив, 2018 Aim. To study epidemiological aspects of disease, class of diseases of the digestive system in the region of the relative risk in Kazakhstan. Materials and methods.
L K Ibraeva +7 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Environmental risk factors associated with the appearance of neoplasms of the digestive system
, 2022 Introducción: el cáncer es una enfermedad de origen multifactorial que se desarrolla tras largos períodos de latencia. Las tendencias actuales en el cáncer del aparato digestivo, específicamente, se han visto afectadas como consecuencia de muchos ...
Pérez-González, Susana +5 more
core +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Ocorrência de neoplasias em cães e gatos da mesorregião metropolitana de Belém, PA entre 2005 e 2010
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2011 Data on the occurrence of cancers in dogs and cats from the Metropolitan Mesoregion of Belém are not available in the literature. This paper describes the occurrence of neoplasms in these species from 2005 to 2010.
A.P.S. Priebe +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
CHARACTERISTICS OF DEATH RATES FROM MALIGNANT TUMORS OF THE DIGESTIVE SYSTEM IN TRANSCARPATIHON REGION AND UKRAINE [PDF]
, 2023 The article analyzes the level and structure of mortality from malignant neoplasms of the digestive organs population of Transcarpathian region and Ukraine as a whole.
Keretsman, A.
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