Results 61 to 70 of about 17,458,229 (270)

Schwann Cells in Digestive System Disorders

, 2022
Proper functioning of the digestive system is ensured by coordinated action of the central and peripheral nervous systems (PNS). Peripheral innervation of the digestive system can be viewed as intrinsic and extrinsic.
Karina Goluba, Vadims Parfejevs, Liga Kunrade, Una Riekstina   +3 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Possible ways of improving the health management system of male staff at atomic industry enterprises

Бюллетень сибирской медицины, 2012
Oncological morbidity among the male workers of the Siberian Group of Chemical Enterprises (SGCE) in 1970—2005 was studied. Increased related risk (in comparison with the standard) of malignant neoplasms of resiratory and digestive tract, urinary ways ...
D. Ye. Kalinkin, A. B. Karpov, R. M. Takhauov, S. M. Khlynin, Yu. A. Samoilova, I. V. Shiryayeva, D. B. Bul’dovich   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Immune Checkpoint Markers in Neuroendocrine Carcinoma of the Digestive System

Frontiers in Oncology, 2020
Digestive system neuroendocrine carcinomas (NECs) are rare neoplasms originating from neuroendocrine cells with a poor prognosis and limited effective treatments.
Jiazhang Xing, Hongyan Ying, Ji Li, Yang Gao, Zhao Sun, Jiarui Li, Chunmei Bai, Yuejuan Cheng, Huanwen Wu   +8 more
doaj   +1 more source

Curative resection in digestive neuroendocrine neoplasms: Recurrence-free survival rate and definition of a risk score for recurrence

, 2016
Curative resection in digestive neuroendocrine neoplasms: Recurrence-free survival rate and definition of a risk score for ...
Elettra Merola
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

EXPERIENCE IN DIAGNOSING RARE DIGESTIVE SYSTEM NEOPLASMS IN LABORATORY MICE

Сибирский онкологический журнал, 2016
Three rare tumors occurring in laboratory mice, namely: myoepithelial carcinoma of the salivary gland, malignant neuroendocrine tumors (carcinoid) of the cecum and insular carcinoma of the pancreas have been described.
V. N. Manskikh, О. S. Gancharova
doaj  

Looking into digestive mixed neuroendocrine – nonneuroendocrine neoplasms: subtypes, prognosis, and predictive factors

, 2020
Mixed neuroendocrine – nonneuroendocrine neoplasms (MiNENs) of the digestive system represent a challenge for both pathologists and clinicians. Their nomenclature has changed several times, and their diagnostic criteria, classification and clinical ...
La Rosa, S., Uccella S., Uccella, S., La Rosa S.   +3 more
core   +1 more source