Results 161 to 170 of about 45,629 (269)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Evaluation of new diagnostic and treatment strategies in the management of the Zollinger-Ellison syndrome

, 2000
Includes bibliography.Despite major advances over the last two decades with the management of patients with Zollinger-Ellison syndrome (ZES), unanswered questions remain concerning the natural history of the disease, the impact of new diagnostics ...
Radebold, Klaus
core  

GENERATIVE AI TOWARDS A COMPARATIVE ANALYSIS OF HOSPITALIZATION RATES AMONG PATIENTS WITH ULCERATIVE COLITIS TREATED WITH INFLIXIMAB, VEDOLIZUMAB, AND TOFACITINIB IN THE PUBLIC HEALTHCARE SYSTEM IN BRAZIL: A NATIONWIDE STUDY. [PDF]

Arq Gastroenterol
Valverde DA, Quaresma AB, Villamil MPG, Moraes TP, Kotze PG.   +4 more
europepmc   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Economic and medical advantages of digestive tract endoscopy

, 1989
U ovom radu analizirana je medicinska i financijska vrijednost određenih dijagnostičkih i opera tivno-terapijskih zahvata (kod gastroenterohepatoloških bolesnika) koji se mogu obaviti endoskopskim i rendgenološkim, odnosno kirurškim putem.
Čandrlić, Ivan, Dubravko Božić, Branimir Zelenka, Božić, Dubravko, Miroslav Volarić, Zelenka, Branimir, Ivan Čandrlić, Paulini, Dubravko, Pospihalj, Boris, Včev, Aleksandar, Dubravko Paulini, Boris Pospihalj, Volarić, Miroslav, Aleksandar Včev   +13 more
core  

Analysis of independent risk factors for postoperative stress ulcers in high-altitude areas. [PDF]

Front Med (Lausanne)
Meng DD, Xie WJ, Chen LJ, Zhao LF, Li YD.   +4 more
europepmc   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Sinus laser-assisted closure for pilonidal sinus disease: a prospective single-center study. [PDF]

Ann Coloproctol
Esposito F, Sacrieru D, Cortes A.
europepmc   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Comparative outcomes of early and late rectourethral fistula: insights from a multicentric retrospective study on multidisciplinary management strategies. [PDF]

Ann Coloproctol
Jeannot P, Roussel E, Dutoit A, Collard M, Christou N, Lefevre JH, Souadka A, Arnaud A, Castaldi A, Bertrand M, Michot N, d'Arcier BF, Tuech JJ, Bruyère F, Giger-Pabst U, Ouaïssi M.   +15 more
europepmc   +1 more source