Results 61 to 70 of about 600,731 (305)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

An Improved Linearization Circuit Used for Optical Rotary Encoders

Measurement Science Review, 2017
Optical rotary encoders generate nonlinear sine and cosine signals in response to a change of angular position that is being measured. Due to the nonlinear shape of encoder output signals, encoder sensitivity to very small changes of angular position is ...
Jovanović Jelena, Denić Dragan, Jovanović Uglješa   +2 more
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Scalable Photonic Digital-to-Analog Converters

Photonics
This work introduces a novel architecture for implementing a parallel coherent photonic digital-to-analog converter (PDAC), designed to transform parallel digital electrical signals into corresponding analog optical output, convertible to analog ...
Md Mahadi Masnad, S. Mohammad Reza Safaee, Najla Najeeb, Kaveh Rahbardar Mojaver, Mohamed Fouda, Emanuel Peinke, Odile Liboiron-Ladouceur   +6 more
doaj   +1 more source

Learning task-based analog-to-digital conversion for MIMO receivers

, 2020
Analog-to-digital conversion allows physical signals to be processed using digital hardware. This conversion consists of two stages: Sampling, which maps a continuous-time signal into discrete-time, and quantization, i.e., representing the continuous ...
Shlezinger, Nir, Eldar, Yonina C., Nir Shlezinger, Ruud J. G. van Sloun, van Sloun, Ruud J.G.; id_orcid, Huijben, Iris, Georgee Tsintsadze, van Sloun, Ruud J.G., Tsintsadze, Georgee, Iris A. M. Huijben, Huijben, Iris; id_orcid, Yonina C. Eldar   +11 more
core   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

All photonic analogue to digital and digital to analogue conversion techniques for digital radio over fibre system applications

, 2011
Copyright @ 2011 IEEEWideband electronic analogue to digital conversion (ADC) systems have critical problems encountered in high-frequency broadband communication systems that the recent electronic ADCs (EADC) have experienced those such as uncertainty ...
Mehdi Fakhraie, S, Nilavalan, R, Abdollahi, SR, Al-Raweshidy, H   +3 more
core  

Experimental Evaluation of 100Cr6 Steel Microindented Surfaces Under Lubricated Nonconformal Point Contacts

Advanced Engineering Materials, EarlyView.
The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi, Pasquale Guglielmi, Gianfranco Palumbo, Giuseppe Carbone   +3 more
wiley   +1 more source

Circuit analysis of RC integration circuits for use in PWM-based DACs

Известия Томского политехнического университета: Промышленная кибернетика
In scientific, educational, and engineering settings, it is often necessary to transmit analog signals to control various actuators. Examples of such devices include motors, valves, dampers, lighting, and audio equipment.
Kirill A. Volobuev, Violetta M. Moskaleva, Igor V. Trubin, Vitaly G. Trubin   +3 more
doaj   +1 more source

Characterization and Design of Analog Integrated Circuits Exploiting Analog Platforms

, 2006
Universal Mobile Telecommunication System (UMTS) front end design is challenging because of the need to optimize power while satisfying a very high dynamic range requirement. At the same time, designing analog circuits for automotive applications is very
Vincis, Federico
core