Results 31 to 40 of about 10,941,453 (300)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Expediente

open access: yesTexto Digital, 2015
Expediente do volume 11 de número 1, 2015.
Texto Digital
doaj   +2 more sources

Digital myths [PDF]

open access: yes, 2001
Much of the early work on information theory was directed towards the study of the transmission of telegraph signals. These theoretical treatments lend themselves to descriptions of signals as digital phenomena they are much less convenient for dealing ...
Monk, John
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Digital demodulator [PDF]

open access: yes, 1982
A digital demodulator for converting pulse code modulated data from phase shift key (PSK) to non return to zero (NRZ) and to biphase data is described. The demodulator is composed of standard integrated logic circuits.
Shull, T. A.
core   +1 more source

Digital Current-Control Schemes [PDF]

open access: yes, 2009
The paper is about comparing the performance of digital signal processor-based current controllers for three-phase active power filters. The wide use of nonlinear loads, such as front-end rectifiers connected to the power distribution systems for dc ...
Bojoi, Iustin Radu   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Our digital children [PDF]

open access: yes, 2014
The power relationship between adults and children in the West is shifting. Factors of age and life experience are becoming counterbalanced by children’s affinity for burgeoning developments in digital technology, where skills developed in online ...
Williams, Peter.
core   +3 more sources

Expediente

open access: yesTexto Digital, 2023
Expediente da Revista Texto Digital, v. 19, n. 1, 2023.
Texto Digital
doaj  

Digital Expungement [PDF]

open access: yes, 2018
Digital technology might lead to the extinction of criminal rehabilitation. In the digital era, criminal history records that were expunged by the state remain widely available through commercial vendors (data brokers) who sell this information to ...
Haber, Eldar
core   +1 more source

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